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Literature summary for 1.17.3.2 extracted from

  • Houston, M.; Esteveze, A.; Chumley, P.; Aslan, M.; Marklund, S.; Parks, D.A.; Freeman, B.A.
    Binding of xanthine oxidase to vascular endothelium (1999), J. Biol. Chem., 274, 4985-4994.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
allopurinol
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0015
-
pterin cell-associated enzyme, determined in intact cell monolayers Bos taurus
0.0016
-
pterin
-
Bos taurus
0.0034
-
xanthine cell-associated enzyme, determined in intact cell monolayers Bos taurus
0.0036
-
xanthine
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information enzyme binds specifically and with high affinity to bovine aortic endothelial cells, increasing cell xanthine oxidase activity up to 10fold, circulating xanthine oxidase may therefore bind to vascular cells, impairing cell function via oxidative mechanisms Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron iron-molybdenum protein Bos taurus
Molybdenum an iron-molybdenum protein Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information
-
Bos taurus
proteolytic modification
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine + 2 H2O + 2 O2
-
Bos taurus urate + 2 H2O2
-
?
pterin + H2O + O2
-
Bos taurus isoxanthopterin + H2O2
-
?
xanthine + H2O + O2 electron acceptor O2 Bos taurus uric acid + H2O2
-
?

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein Bos taurus