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Literature summary for 1.17.3.2 extracted from

  • Li, H.; Samouilov, A.; Liu, X.; Zweier, J.L.
    Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation (2004), J. Biol. Chem., 279, 16939-16946.
    View publication on PubMed
Search for more literature for 1.17.3.2

Activating Compound

Activating Compound Comment Organism Structure
diphenylene iodonium chloride strongly inhibits xanthine oxidase mediated NO generation with NADH serving as reducing substrate, with xanthine or 2,3-dihydroxybenzaldehyde as reducing substrates, NO generation is increased more than six times Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
diphenylene iodonium chloride strongly inhibits xanthine oxidase mediated NO generation with NADH serving as reducing substrate, with xanthine or 2,3-dihydroxybenzaldehyde as reducing substrates, NO generation is increased more than six times Bos taurus
O2 competitive inhibitor of NO production Bos taurus
oxypurinol inhibits NO generation triggered by xanthine, NADH or 2,3-dihydroxybenzaldehyde Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart xanthine oxidase mediated nitrite reduction can be a source of NO in heart tissue under conditions of tissue normoxia, and it is further increased with mild hypoxia Bos taurus
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milk
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nitrite + 2,3-dihydroxybenzaldehyde NO generation occurs under aerobic conditions and is regulated by O2 tension, pH, nitrite, and reducing substrate concentrations Bos taurus NO + ?
-
 ?
nitrite + NADH NO generation occurs under aerobic conditions and is regulated by O2 tension, pH, nitrite, and reducing substrate concentrations Bos taurus NO + NAD+ + H2O
-
 ?
nitrite + xanthine NO generation occurs under aerobic conditions and is regulated by O2 tension, pH, nitrite, and reducing substrate concentrations Bos taurus NO + ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
 Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
6 7.6 under aerobic conditions, NO generation increases more than three times as the pH value decreases from pH 7.4 to 6.0 Bos taurus