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Literature summary for 1.17.3.2 extracted from

  • Souza, C.F.; Verdi, C.M.; Baldissera, M.D.; Doleski, P.H.; Vizzotto, B.S.; Santos, R.C.V.; Baldisserotto, B.
    Xanthine oxidase activity affects pro-oxidative and pro-inflammatory profiles in spleen of silver catfish experimentally infected with Aeromonas caviae (2017), Microb. Pathog., 113, 25-28 .
    View publication on PubMed
Search for more literature for 1.17.3.2

Metals/Ions

Metals/Ions Comment Organism Structure
Molybdenum in the molybdopterin cofactor Bagrus bajad

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxanthine + NAD+ + H2O Bagrus bajad
-
 xanthine + NADH + H+
-
 ?
xanthine + H2O + O2 Bagrus bajad
-
 urate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Bagrus bajad
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
 Bagrus bajad
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxanthine + NAD+ + H2O
-
 Bagrus bajad xanthine + NADH + H+
-
 ?
xanthine + H2O + O2
-
 Bagrus bajad urate + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
XOR
-
 Bagrus bajad

Cofactor

Cofactor Comment Organism Structure
molybdopterin
-
 Bagrus bajad
NAD+
-
 Bagrus bajad

Expression

Organism Comment Expression
Bagrus bajad the enzyme is upregulated and enzyme activity increases in the spleen of animals infected with Aeromonas caviae, as do the splenic levels of uric acid, reactive oxygen species, and metabolites of nitric oxide (NOx), compared to the uninfected control group up

General Information

General Information Comment Organism
malfunction upregulation of splenic xanthine oxidase activity contributes to disease pathogenesis of Aeromonas caviae infection, as well as whether it may be considered a pathway involved in reactive oxygen species (ROS) and nitric oxide (NO) production. Excessive uric acid induces the release of pro-inflammatory mediators, such as ROS and NOx, which contribute to disease pathophysiology, in spleen tissue they contribute to oxidation and inflammation of the tissue Bagrus bajad
physiological function xanthine oxidoreductase (XOR) is a molybdopterin-containing enzyme that catalyzes the oxidation of hypoxanthine to xanthine, and further generates uric acid from xanthine in the purine metabolic pathway Bagrus bajad