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Literature summary for 1.17.4.1 extracted from

  • Ong, S.P.; McFarlan, S.C.; Hogenkamp, H.P.C.
    2'-C-Methyladenosine and 2'-C-methyluridine 5'-diphosphates are mechanism-based inhibitors of ribonucleoside diphosphate reductase from Corynebacterium nephridii (1993), Biochemistry, 32, 11397-11404.
    View publication on PubMed
Search for more literature for 1.17.4.1

Inhibitors

Inhibitors Comment Organism Structure
2'-methyladenosine 5'-diphosphate probably mechanism based inhibition, competitive inhibition vs. ADP and GDP Corynebacterium nephridii
2'-methyluridine 5'-diphosphate probably mechanism based inhibition, competitive inhibition vs. UDP and CDP Corynebacterium nephridii

Organism

Organism UniProt Comment Textmining
Corynebacterium nephridii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-methyladenosine 5'-diphosphate + reduced dithiothreitol
-
 Corynebacterium nephridii adenine + 2'-deoxy-2'-methyladenosine + H2O 5% reduction to 2'-deoxy-2'-methyladenosine, adenine is the major product besides other unidentified products ?
2'-methyluridine 5'-diphosphate + reduced dithiothreitol
-
 Corynebacterium nephridii uracil + H2O + ? uracil is the major product, unidentified minor product may be 2'-deoxy-2'-methyluridine ?
ribonucleoside diphosphate + reduced thioredoxin
-
 Corynebacterium nephridii 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0037
-
 2'-methyladenosine 5'-diphosphate vs. ADP Corynebacterium nephridii
0.0079
-
 2'-methyladenosine 5'-diphosphate vs. GDP Corynebacterium nephridii
0.084
-
 2'-methyluridine 5'-diphosphate vs. UDP Corynebacterium nephridii
0.115
-
 2'-methyluridine 5'-diphosphate vs. CDP Corynebacterium nephridii