Literature summary for 1.17.4.1 extracted from

Cerqueira, N.M.; Fernandes, P.A.; Eriksson, L.A.; Ramos, M.J.
Dehydration of ribonucleotides catalyzed by ribonucleotide reductase: the role of the enzyme (2006), Biophys. J., 90, 2109-2119.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin	role of enzyme in second step of catalytic mechanism which corresponds to the protonation/elimination of the substrates C2 hydroxyl group is mainly entropic by placing the substrate and the two reactive residues in a position that allows for the highly favorable concerted trimolecular reaction, and to protect the enzyme radical from the solvent	Escherichia coli	a

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Release 2023.1 (January 2023)