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Literature summary for 1.17.4.1 extracted from

  • Kowol, C.R.; Berger, R.; Eichinger, R.; Roller, A.; Jakupec, M.A.; Schmidt, P.P.; Arion, V.B.; Keppler, B.K.
    Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase (2007), J. Med. Chem., 50, 1254-1265.
    View publication on PubMed
Search for more literature for 1.17.4.1

Inhibitors

Inhibitors Comment Organism Structure
2-acetylpyridine N,N-dimethylthiosemicarbazonato-N,N,S-dichlorogallium(III)
-
 Homo sapiens
2-acetylpyridine N-pyrrolidinylthiosemicarbazonato-N,N,S-dichlorogallium(III)
-
 Homo sapiens
additional information synthesis, characterization, cytotoxicity in human cell lines, and interaction with ribonucleotide reductase of gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones, overview, gallium(III) enhances, whereas iron(III) weakens the cytotoxicity of the ligands Homo sapiens
additional information synthesis, characterization, and interaction with ribonucleotide reductase subunit R2 of gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones, overview, gallium(III) enhances, whereas iron(III) weakens the cytotoxicity of the ligands Mus musculus
[bis(2-acetylpyridine N,N-dimethylthiosemicarbazonato)-N,N,S-gallium(III)] hexafluorophosphate
-
 Homo sapiens
[bis(2-acetylpyridine N,N-dimethylthiosemicarbazonato)-N,N,S-iron(III)] hexafluorophosphate
-
 Homo sapiens
[bis(2-acetylpyridine N,N-dimethylthiosemicarbazonato)-N,N,S-iron(III)] tetrachloroferrate(III)
-
 Homo sapiens
[bis(2-acetylpyridine N-pyrrolidinylthiosemicarbazonato)-N,N,S-gallium(III)] hexafluorophosphate
-
 Homo sapiens
[bis(2-acetylpyridine N-pyrrolidinylthiosemicarbazonato)-N,N,S-iron(III)] hexafluorophosphate
-
 Homo sapiens
[bis(2-acetylpyridine N-pyrrolidinylthiosemicarbazonato)-N,N,S-iron(III)] tetrachloroferrate(III)
-
 Homo sapiens
[bis(acetylpyrazine N,N-dimethylthiosemicarbazonato)-N,N,S-gallium(III)] hexafluorophosphate
-
 Homo sapiens
[bis(acetylpyrazine N,N-dimethylthiosemicarbazonato)-N,N,S-iron(III)] hexafluorophosphate
-
 Homo sapiens
[bis(acetylpyrazine N,N-dimethylthiosemicarbazonato)-N,N,S-iron(III)] tetrachloroferrate(III)
-
 Homo sapiens
[bis(acetylpyrazine N-piperidinylthiosemicarbazonato)-N,N,S-gallium(III)] hexafluorophosphate
-
 Homo sapiens
[bis(acetylpyrazine N-piperidinylthiosemicarbazonato)-N,N,S-iron(III)] hexafluorophosphate
-
 Homo sapiens
[bis(acetylpyrazine N-piperidinylthiosemicarbazonato)-N,N,S-iron(III)] tetrachloroferrate(III)
-
 Homo sapiens
[bis(acetylpyrazine N-pyrrolidinylthiosemicarbazonato)-N,N,S-gallium(III)] hexafluorophosphate
-
 Homo sapiens
[bis(acetylpyrazine N-pyrrolidinylthiosemicarbazonato)-N,N,S-iron(III)] hexafluorophosphate
-
 Homo sapiens
[bis(acetylpyrazine N-pyrrolidinylthiosemicarbazonato)-N,N,S-iron(III)] tetrachloroferrate(III)
-
 Homo sapiens
[FeCl4] 2-acetylpyridine N,N-dimethylthiosemicarbazone Ga(III) and Fe(III) complexes destroy the tyrosyl radical of the presumed target ribonucleotide reductase Mus musculus
[FeCl4] 2-acetylpyridine N-pyrrolidinylthiosemicarbazone
-
 Mus musculus
[FeCl4] acetylpyrazine N,N-dimethylthiosemicarbazone
-
 Mus musculus
[FeCl4] acetylpyrazine N-piperidinylthiosemicarbazone
-
 Mus musculus
[FeCl4] acetylpyrazine N-pyrrolidinylthiosemicarbazone
-
 Mus musculus
[GalCl2] 2-acetylpyridine N,N-dimethylthiosemicarbazone Ga(III) and Fe(III) complexes destroy the tyrosyl radical of the presumed target ribonucleotide reductase Mus musculus
[GalCl2] 2-acetylpyridine N-pyrrolidinylthiosemicarbazone
-
 Mus musculus
[GalCl2] acetylpyrazine N,N-dimethylthiosemicarbazone
-
 Mus musculus
[GalCl2] acetylpyrazine N-piperidinylthiosemicarbazone
-
 Mus musculus
[GalCl2] acetylpyrazine N-pyrrolidinylthiosemicarbazone
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus
Mg2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
41M cell
-
 Homo sapiens
-
SK-BR-3 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
RNR
-
 Mus musculus
RNR
-
 Homo sapiens