Literature summary for 1.17.4.4 extracted from

Harrington, D.J.; Underwood, S.; Morse, C.; Shearer, M.J.; Tuddenham, E.G.; Mumford, A.D.
Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1 (2005), Thromb. Haemost., 93, 23-26.

Search for more literature for 1.17.4.4

Application

Application	Comment	Organism
medicine	the enzyme is the therapeutic target site for warfarin, an anticoagulant that is prescribed widely for the treatment and prevention of thrombosis. Point mutations in VKORC1 may be an important, though rare, cause of warfarin resistance in anticoagulation clinic populations	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
V66M	mutation is responsible for warfarin resistance phenotype	Homo sapiens
V66M	naturally occuring VKORC1 mutant showing warfarin-resistance, patients with this mutation need a very high dosage of anticoagulants in therapy, overview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	pharmacodynamics of resistance to warfarin, overview	Homo sapiens
warfarin	the enzyme is the therapeutic target site for warfarin, an anticoagulant that is prescribed widely for the treatment and prevention of thrombosis. Point mutations in VKORC1 may be an important, though rare, cause of warfarin resistance in anticoagulation clinic populations. V66M mutation is responsible for warfarin resistance phenotype	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the enzyme is involved in coagulation factor activity	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	mutant V66M	-
Homo sapiens	Q9BQB6	wild-type enzyme	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is involved in coagulation factor activity	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
vitamin K epoxide reductase complex subunit 1	-	Homo sapiens
VKORC1	-	Homo sapiens

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Release 2023.1 (January 2023)