Cloned (Comment) | Organism |
---|---|
gene VKORC1, genotyping | Mus musculus |
gene VKORC1, genotyping | Mus musculus domesticus |
Protein Variants | Comment | Organism |
---|---|---|
W59G | the single nucleotide polymorphism T175G in gene VKORC1 causes 4-hydroxycoumarin derivative-resistance | Mus musculus domesticus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | mechanism of 4-hydroxycoumarin derivative-resistance, overview | Mus musculus domesticus | |
warfarin | inhibition mechanism, overview | Mus musculus | |
warfarin | slight inhibition, mechanism, overview | Mus musculus domesticus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Mus musculus | |
additional information | - |
additional information | kinetics | Mus musculus domesticus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Mus musculus domesticus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Mus musculus | i.e. vitamin K 2,3-epoxide | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Mus musculus domesticus | i.e. vitamin K 2,3-epoxide | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
warfarin-susceptible strain | - |
Mus musculus domesticus | - |
warfarin-resistant strain | - |
Purification (Comment) | Organism |
---|---|
partially by microsome preparation | Mus musculus |
partially by microsome preparation | Mus musculus domesticus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Mus musculus domesticus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Mus musculus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Mus musculus domesticus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? |
Synonyms | Comment | Organism |
---|---|---|
vitamin K epoxide reductase | - |
Mus musculus |
vitamin K epoxide reductase | - |
Mus musculus domesticus |
VKOR | - |
Mus musculus |
VKOR | - |
Mus musculus domesticus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
30 | - |
assay at | Mus musculus domesticus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Mus musculus domesticus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Mus musculus | |
additional information | - |
additional information | inhibition kinetics | Mus musculus domesticus | |
0.006 | - |
warfarin | pH 7.4, 30°C | Mus musculus |