Literature summary for 1.17.4.4 extracted from

Rutkevich, L.A.; Williams, D.B.
Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum (2012), Mol. Biol. Cell, 23, 2017-2027.

Search for more literature for 1.17.4.4

Inhibitors

Inhibitors	Comment	Organism	Structure
warfarin	overnight treatment with the drug produces similar phenotypes to 7 days of siRNA-mediated VKOR depletion	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum membrane	the enzyme contains a VKOR CXXC motif	Homo sapiens	5789	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
vitamin K epoxide reductase	-	Homo sapiens
VKOR	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	depletion of the protein disulfide formation activity of the enzyme in the endoplasmic reticulum results in cell death. Knockdown of the enzyme results in no detectable increase in expression of the ER Hsp70 chaperone BiP nor evidence of Xbp-1 splicing when measured on the final day of knockdown, indicating that an unfolded protein response is not being induced	Homo sapiens
metabolism	VKOR contributes to an oxidizing endoplasmic reticulum environment under conditions of endoplasmic reticulum oxidoreductin and peroxiredoxin IV deficiency	Homo sapiens
physiological function	vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum,depletion of the activity results in cell death, both peroxiredoxin IV and VKOR support cell growth and viability in the face of endoplasmic reticulum oxidoreductin depletion	Homo sapiens

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Release 2023.1 (January 2023)