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Literature summary for 1.2.1.101 extracted from

  • Forseth, R.; Amaike, S.; Schwenk, D.; Affeldt, K.; Hoffmeister, D.; Schroeder, F.; Keller, N.
    Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus (2013), Angew. Chem. Int. Ed. Engl., 52, 1590-1594 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.101

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + NADPH + H+ + ATP Aspergillus flavus the lna and lnb biosynthetic pathways appear to be part of a signaling network that controls the formation of sclerotia, a resilient overwintering structure L-tyrosinal + NADP+ + AMP + diphosphate
-
 ?
L-tyrosine + NADPH + H+ + ATP Aspergillus flavus ATCC 200026 the lna and lnb biosynthetic pathways appear to be part of a signaling network that controls the formation of sclerotia, a resilient overwintering structure L-tyrosinal + NADP+ + AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus flavus
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-
-
Aspergillus flavus B8NTZ9
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-
Aspergillus flavus ATCC 200026 B8NTZ9
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-tyrosine + NADPH + H+ + ATP LnaA is somewhat D/L-unspecific and also activates D-Tyr Aspergillus flavus D-tyrosinal + NADP+ + AMP + diphosphate
-
 ?
D-tyrosine + NADPH + H+ + ATP LnaA is somewhat D/L-unspecific and also activates D-Tyr Aspergillus flavus ATCC 200026 D-tyrosinal + NADP+ + AMP + diphosphate
-
 ?
L-tyrosine + NADPH + H+ + ATP the lna and lnb biosynthetic pathways appear to be part of a signaling network that controls the formation of sclerotia, a resilient overwintering structure Aspergillus flavus L-tyrosinal + NADP+ + AMP + diphosphate
-
 ?
L-tyrosine + NADPH + H+ + ATP LnaA is somewhat D/L-unspecific and also activates D-Tyr Aspergillus flavus L-tyrosinal + NADP+ + AMP + diphosphate
-
 ?
L-tyrosine + NADPH + H+ + ATP LnbA specifically activates L-Tyr Aspergillus flavus L-tyrosinal + NADP+ + AMP + diphosphate
-
 ?
L-tyrosine + NADPH + H+ + ATP the lna and lnb biosynthetic pathways appear to be part of a signaling network that controls the formation of sclerotia, a resilient overwintering structure Aspergillus flavus ATCC 200026 L-tyrosinal + NADP+ + AMP + diphosphate
-
 ?
L-tyrosine + NADPH + H+ + ATP LnaA is somewhat D/L-unspecific and also activates D-Tyr Aspergillus flavus ATCC 200026 L-tyrosinal + NADP+ + AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
L-tyrosine reductase LnaA
-
 Aspergillus flavus
L-tyrosine reductase LnbA
-
 Aspergillus flavus

General Information

General Information Comment Organism
malfunction in the DlnaA, KD::lnbA double-mutant strain, in which both the lna and lnb pathways are disrupted, formation of sclerotia is strongly suppressed relative to the wild-type Aspergillus flavus
physiological function the lna and lnb biosynthetic pathways appear to be part of a signaling network that controls the formation of sclerotia, a resilient overwintering structure Aspergillus flavus