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Literature summary for 1.2.1.104 extracted from

  • Bisswanger, H.
    Substrate specificity of the pyruvate dehydrogenase complex from Escherichia coli (1981), J. Biol. Chem., 256, 815-822.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-Bromopyruvate
-
Escherichia coli
acetaldehyde weak Escherichia coli
alpha-Ketobutyric acid
-
Escherichia coli
alpha-Ketocaproate
-
Escherichia coli
alpha-ketooctanoic acid
-
Escherichia coli
alpha-ketovalerate
-
Escherichia coli
beta-Hydroxypyruvate
-
Escherichia coli
Fluoropyruvate
-
Escherichia coli
glyoxylic acid weak Escherichia coli
L-lactate weak Escherichia coli
phenylpyruvate
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + lipoamide Escherichia coli in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate S-acetyldihydrolipoamide + CO2
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + lipoamide in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate Escherichia coli S-acetyldihydrolipoamide + CO2
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0014
-
Fluoropyruvate assay with whole enzyme complex Escherichia coli
0.028
-
Bromopyruvate assay with whole enzyme complex Escherichia coli
0.5
-
glyoxylic acid assay with whole enzyme complex Escherichia coli
1
-
beta-Hydroxypyruvate assay with whole enzyme complex Escherichia coli
2.25
-
alpha-Ketobutyric acid assay with whole enzyme complex Escherichia coli