Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-Bromopyruvate | - |
Escherichia coli | |
acetaldehyde | weak | Escherichia coli | |
alpha-Ketobutyric acid | - |
Escherichia coli | |
alpha-Ketocaproate | - |
Escherichia coli | |
alpha-ketooctanoic acid | - |
Escherichia coli | |
alpha-ketovalerate | - |
Escherichia coli | |
beta-Hydroxypyruvate | - |
Escherichia coli | |
Fluoropyruvate | - |
Escherichia coli | |
glyoxylic acid | weak | Escherichia coli | |
L-lactate | weak | Escherichia coli | |
phenylpyruvate | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + lipoamide | Escherichia coli | in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate | S-acetyldihydrolipoamide + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + lipoamide | in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate | Escherichia coli | S-acetyldihydrolipoamide + CO2 | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0014 | - |
Fluoropyruvate | assay with whole enzyme complex | Escherichia coli | |
0.028 | - |
Bromopyruvate | assay with whole enzyme complex | Escherichia coli | |
0.5 | - |
glyoxylic acid | assay with whole enzyme complex | Escherichia coli | |
1 | - |
beta-Hydroxypyruvate | assay with whole enzyme complex | Escherichia coli | |
2.25 | - |
alpha-Ketobutyric acid | assay with whole enzyme complex | Escherichia coli |