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Literature summary for 1.2.1.104 extracted from

  • Liu, X.; Bisswanger, H.
    Interaction of thiamin diphosphate with phosphorylated and dephosphorylated mammalian pyruvate dehydrogenase complex (2005), Biol. Chem., 386, 11-18.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Fluoropyruvate acts as substrate analogue, competitive Bos taurus
Pyruvamide acts as substrate analogue, competitive Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
pyruvate pH 7.6, 30°C, catalytic subunit E1 Bos taurus
0.072
-
pyruvate pH 7.6, 30°C, overall reaction of complex Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA + NAD+
-
Bos taurus acetyl-CoA + CO2 + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate Km value 0.0034 mM for overall reaction Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.02
-
Fluoropyruvate pH 7.6, 30°C, overall reaction of complex Bos taurus
0.02
-
Pyruvamide pH 7.6, 30°C, overall reaction of complex Bos taurus