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Literature summary for 1.2.1.104 extracted from

  • McFate, T.; Mohyeldin, A.; Lu, H.; Thakar, J.; Henriques, J.; Halim, N.D.; Wu, H.; Schell, M.J.; Tsang, T.M.; Teahan, O.; Zhou, S.; Califano, J.A.; Jeoung, N.H.; Harris, R.A.; Verma, A.
    Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells (2008), J. Biol. Chem., 283, 22700-22708.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information pyruvate dehydrogenase complex inhibition occurs via enhanced expression of pyruvate dehydrogenase kinase-1, which results in inhibitory phosphorylation of the pyruvate dehydrogenase alpha subunit, knockdown of pyruvate dehydrogenase kinase-1 via short hairpin RNA lowers inhibitory PDHalpha phosphorylation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HNSCC cell
-
 Homo sapiens
-
JHU-O22 cell
-
 Homo sapiens
-
UM-SCC-22A cell
-
 Homo sapiens
-
UM-SCC-22B cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA + NAD+
-
 Homo sapiens acetyl-CoA + CO2 + NADH
-
 ?

Synonyms

Synonyms Comment Organism
PDHalpha
-
 Homo sapiens
pyruvate dehydrogenase alpha subunit
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
 Homo sapiens