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Literature summary for 1.2.1.104 extracted from
- Regulation of pyruvate dehydrogenase in the common killifish, Fundulus heteroclitus, during hypoxia exposure (2008), Am. J. Physiol. Regul. Integr. Comp. Physiol., 295, R979-R990.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| pyruvate dehydrogenase phosphatase | activates PDH by dephosphorylation | Fundulus heteroclitus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| pyruvate dehydrogenase kinase | deactivates PDH by phosphorylation | Fundulus heteroclitus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Fundulus heteroclitus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Fundulus heteroclitus | - |
subspecies Fundulus heteroclitus heteroclitus | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Fundulus heteroclitus | - |
| gill | - |
Fundulus heteroclitus | - |
| heart | - |
Fundulus heteroclitus | - |
| intestine | - |
Fundulus heteroclitus | - |
| liver | - |
Fundulus heteroclitus | - |
| muscle | - |
Fundulus heteroclitus | - |
| spleen | - |
Fundulus heteroclitus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate + CoA + NAD+ | - |
Fundulus heteroclitus | acetyl-CoA + CO2 + NADH | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDH | - |
Fundulus heteroclitus |
| pyruvate dehydrogenase | - |
Fundulus heteroclitus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Fundulus heteroclitus | |
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