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Literature summary for 1.2.1.104 extracted from

  • Lee, J.; Oh, S.; Bhattacharya, S.; Zhang, Y.; Florens, L.; Washburn, M.P.; Workman, J.L.
    The plasticity of the pyruvate dehydrogenase complex confers a labile structure that is associated with its catalytic activity (2020), PLoS ONE, 15, e0243489 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.104

General Stability

General Stability Organism
PDC displays size versatility in an ionic strength-dependent manner. PDC (yPDC) is a salt-labile complex that dissociates into sub-megadalton individual components even under physiological ionic strength. Each oligomeric component of PDC displays a larger size than expected. The activity of PDC is reduced in higher ionic strength Saccharomyces cerevisiae
PDC displays size versatility in an ionic strength-dependent manner. PDC (yPDC) is a salt-labile complex that dissociates into sub-megadalton individual components even under physiological ionic strength. Each oligomeric component of PDC displays a larger size than expected. The activity of PDC is reduced in higher ionic strength Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Saccharomyces cerevisiae 5739
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
230000
-
 gel filtration, mammalian E1p, mE1palpha (PDHA1) and mE1pbeta (PDHB1), and mE3 components are detected mostly in sub-megadalton size fractions of the high ionic strength fraction Homo sapiens
230000 440000 gel filtration, enzyme isolated from nuclei-enriched low sedimentation rate fraction Saccharomyces cerevisiae
1000000
-
 and 2000000, gel filtration, enzyme isolated from mitochondria-enriched high sedimentation rate fraction Saccharomyces cerevisiae
2000000
-
 and 1000000, gel filtration, enzyme isolated from mitochondria-enriched high sedimentation rate fraction Saccharomyces cerevisiae
2000000
-
 gel filtration, E2 component eluted only as a megadalton complex even in the high sedimentation rate fraction Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08559 and P11177 and O00330 and P10515 and P09622 P08559 i.e. subunit PdhA1, cf. EC 1.2.4.1, P11177 i.e. subunit PdhB1, cf. EC 1.2.4.1, O00330 i.e. subunit PdhX, P10515 i.e. subunit DlaT, cf. EC 2.3.1.12, P09622 i.e. subunit Dld, cf. EC 1.8.1.4, respectively
-
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae P16387 E1 component subunit alpha
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Saccharomyces cerevisiae BY4741
-
-
-
Saccharomyces cerevisiae BY4741 P16387 E1 component subunit alpha
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
More PDC displays size versatility in an ionic strength-dependent manner. PDC is a salt-labile complex that dissociates into sub-megadalton individual components even under physiological ionic strength. Each oligomeric component of PDC displays a larger size than expected. The activity of PDC is reduced in higher ionic strength Saccharomyces cerevisiae
More PDC displays size versatility in an ionic strength-dependent manner. PDC is a salt-labile complex that dissociates into sub-megadalton individual components even under physiological ionic strength. Each oligomeric component of PDC displays a larger size than expected. The activity of PDC is reduced in higher ionic strength Homo sapiens
More the pyruvate dehydrogenase complex PDC displays size versatility in an ionic strength-dependent manner. Yeast PDC is a salt-labile complex that dissociates into submegadalton individual components even under physiological ionic strength. The ionic strength can modulate its catalytic activity. E1 elutes at fractions for about 440 kDa proteins that mainly contain E1alpha, E1beta, and a nominal amount of E2. E3 elutes at fractions for about 230 kDa, which contain mostly E3 Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Pda1 cf. EC 1.2.4.1 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the pyruvate dehydrogenase complex PDC displays size versatility in an ionic strength-dependent manner. Yeast PDC is a salt-labile complex that dissociates into submegadalton individual components even under physiological ionic strength. The ionic strength can modulate its catalytic activity Saccharomyces cerevisiae