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Literature summary for 1.2.1.105 extracted from

  • Iwata, H.; Tonomura, H.; Matsuda, T.
    Transketolase and 2-oxoglutarate dehydrogenase activities in the brain and liver of the developing rat (1988), Experientia, 44, 780-781.
    View publication on PubMed
Search for more literature for 1.2.1.105

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Reaction

Reaction Comment Organism Reaction ID
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
brain postnatal increase of activity Rattus norvegicus
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liver postnatal increase of activity Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + lipoamide
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 Rattus norvegicus S-succinyldihydrolipoamide + CO2
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