Application | Comment | Organism |
---|---|---|
medicine | succinyl phosphonate and its esters may be useful in studying the effects of reduced KGDHC activity on neuronal and brain function | Homo sapiens |
medicine | succinyl phosphonate and its esters may be useful in studying the effects of reduced KGDHC activity on neuronal and brain function | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-oxo-4-phosphonobutanoic acid | 0.01 mM completely inhibits even in the presence of a 200fold higher concentration of its substrate 2-oxoglutarate | Bos taurus | |
4-oxo-4-phosphonobutanoic acid | 0.01 mM produce 70% inhibition | Homo sapiens | |
4-[(2-carboxyethoxy)(hydroxy)phosphoryl]-4-oxobutanoic acid | 0.01 mM completely inhibits even in the presence of a 200fold higher concentration of its substrate 2-oxoglutarate | Bos taurus | |
4-[(2-carboxyethoxy)(hydroxy)phosphoryl]-4-oxobutanoic acid | 0.01 mM produce 70% inhibition | Homo sapiens | |
4-[ethoxy(hydroxy)phosphoryl]-4-oxobutanoic acid | 0.01 mM completely inhibits even in the presence of a 200fold higher concentration of its substrate 2-oxoglutarate | Bos taurus | |
4-[ethoxy(hydroxy)phosphoryl]-4-oxobutanoic acid | 0.01 mM produce 70% inhibition | Homo sapiens | |
ethyl 4-[ethoxy(hydroxy)phosphoryl]-4-oxobutanoate | only inhibitory after preincubation, release of charged groups by cellular esterases and activation in intact cells | Homo sapiens | |
additional information | ethyl 4-[ethoxy(hydroxy)phosphoryl]-4-oxobutanoate and triethyl esters of succinyl phosphonate are ineffective | Bos taurus | |
triethyl ester of succinyl phosphonate | only inhibitory after preincubation, release of charged groups by cellular esterases and activation in intact cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
culture medium | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.1 | - |
- |
Bos taurus |
0.2 | - |
- |
Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Bos taurus | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-ketoglutarate dehydrogenase complex | - |
Homo sapiens |
alpha-ketoglutarate dehydrogenase complex | - |
Bos taurus |
KGDHC | - |
Homo sapiens |
KGDHC | - |
Bos taurus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.7 | 6 | - |
Bos taurus |