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Literature summary for 1.2.1.105 extracted from

  • Shi, Q.; Risa, O.; Sonnewald, U.; Gibson, G.E.
    Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis (2009), J. Neurochem., 109 Suppl 1, 214-221.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.105

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell The HEK-293 subline E2k-67 shows about 30% reduced KGDHC activity; control line E2k-100 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
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 Homo sapiens [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
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 ?

Synonyms

Synonyms Comment Organism
alpha-ketoglutarate dehydrogenase complex
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 Homo sapiens
E1k
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 Homo sapiens
KGDHC
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens