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Literature summary for 1.2.1.105 extracted from

  • Zuendorf, G.; Kahlert, S.; Bunik, V.I.; Reiser, G.
    alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ (2009), Neuroscience, 158, 610-616.
    View publication on PubMed
Search for more literature for 1.2.1.105

Inhibitors

Inhibitors Comment Organism Structure
succinyl phosphonate specific inhibitor of cellular KGDHC, 20% inhibition at 0.2 mM Rattus norvegicus
succinyl phosphonate triethyl ester specific inhibitor of cellular KGDHC, 44% inhibition at 0.5 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus KGDHC contributes to neuronal reactive oxygen species increase in situ ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Rattus norvegicus
-
neuron hippocampal neuron Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Rattus norvegicus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ?
additional information KGDHC contributes to neuronal reactive oxygen species increase in situ Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha-ketoglutarate dehydrogenase complex
-
 Rattus norvegicus
KGDHC
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus
thiamine diphosphate
-
 Rattus norvegicus