Literature summary for 1.2.1.105 extracted from

Bailey, P.S.J.; Ortmann, B.M.; Martinelli, A.W.; Houghton, J.W.; Costa, A.S.H.; Burr, S.P.; Antrobus, R.; Frezza, C.; Nathan, J.A.
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex (2020), Nat. Commun., 11, 4046 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q02218 and P36957 and P09622	Q02218 i.e. component E1, cf. EC 1.2.4.2, P36957 i.e. component E2, cf. EC 2.3.1.61, P09622 i.e. component E3, cf. EC 1.8.1.4	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	mitochondrial hydrolase ABHD11 signals changes in mitochondrial 2-oxoglutarate metabolism. ABHD11 loss or inhibition drives a rapid increase in 2-oxoglutarate levels by impairing lipoylation of the 2-oxoglutarate dehydrogenase complex. ABHD11 associates with the OGDHc and maintains catalytic activity of lipoyl domain by preventing the formation of lipoyl adducts	Homo sapiens

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Release 2023.1 (January 2023)