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Literature summary for 1.2.1.12 extracted from

  • Loecken, E.M.; Guengerich, F.P.
    Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations (2008), Chem. Res. Toxicol., 21, 453-458.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli TRG8 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diepoxybutane incubation of GAPDH with bis-electrophiles results in inhibition of its catalytic activity, but only at high concentrations of diepoxybutane Homo sapiens
iodoacetamide
-
Homo sapiens
additional information not inhibited by DMSO, dibromomethane and 1,2-dibromoethane Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
Homo sapiens 3-phospho-D-glyceroyl phosphate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
GAPDH
-
Homo sapiens
glyceraldehyde 3-phosphate dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens