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Literature summary for 1.2.1.16 extracted from

  • Fuhrer, T.; Chen, L.; Sauer, U.; Vitkup, D.
    Computational prediction and experimental verification of the gene encoding the NAD+/NADP+-dependent succinate semialdehyde dehydrogenase in Escherichia coli (2007), J. Bacteriol., 189, 8073-8078.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
gamma-aminobutyrate induces GabD dehydrogenase Escherichia coli

Application

Application Comment Organism
additional information the NADP+-dependent succinate semialdehyde dehydrogenase activity encoded by gabD appears to be important for nitrogen metabolism under N limitation conditions Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed as His-tagged GabD Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information gabD knockout mutant has a limited capacity to metabolize gamma-aminobutyrate Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli BW25113
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His-tagged GabD dehydrogenase purified from cell extracts with HiTrap affinity columns Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate semialdehyde + NADP+ + H2O
-
Escherichia coli succinate + NADPH + H+
-
?
succinate semialdehyde + NADP+ + H2O
-
Escherichia coli BW25113 succinate + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
GabD dehydrogenase
-
Escherichia coli
SSADH
-
Escherichia coli
succinate semialdehyde dehydrogenase
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADP+ GabD dehydrogenase is specific for NADP+ Escherichia coli