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Literature summary for 1.2.1.18 extracted from

  • Goodwin, G.W.; Rougraff, P.M.; Davis, E.J.; Harris, R.A.
    Purification and characterization of methylmalonate-semialdehyde dehydrogenase from rat liver. Identity to malonate-semialdehyde dehydrogenase (1989), J. Biol. Chem., 264, 14965-14971.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NADH competitive with NAD+ Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0045
-
3-oxopropanoate
-
Rattus norvegicus
0.0053
-
2-Methyl-3-oxopropanoate
-
Rattus norvegicus
0.03
-
CoA
-
Rattus norvegicus
0.15
-
NAD+
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
4 * 58000, SDS-PAGE Rattus norvegicus
250000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.83
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-3-oxopropanoate + CoA + NAD+ both stereoisomers Rattus norvegicus propanoyl-CoA + CO2 + NADH
-
?
3-oxopropanoate + CoA + NAD+
-
Rattus norvegicus acetyl-CoA + CO2 + NADH
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 58000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
reaction with 2-methyl-3-oxopropanoate Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Rattus norvegicus