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Literature summary for 1.2.1.22 extracted from

  • Sridhara, S.; Wu, T.T.
    Purification and properties of lactaldehyde dehydrogenase from Escherichia coli (1969), J. Biol. Chem., 244, 5233-5238.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cysteine
-
Escherichia coli
glutathione
-
Escherichia coli

General Stability

General Stability Organism
dialysis in absence of EDTA and beta-mercaptoethanol: complete loss of activity Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
Cu2+ 85% inhibition at 0.1 mM Escherichia coli
iodoacetate
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
sucrose density gradient centrifugation Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactaldehyde + NAD+ Escherichia coli essential for catabolism of 1,2-propanediol (S)-lactate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
constitutive mutant
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.1
-
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactaldehyde + NAD+ essential for catabolism of 1,2-propanediol Escherichia coli (S)-lactate + NADH
-
?
(S)-lactaldehyde + NAD+ + H2O
-
Escherichia coli (S)-lactate + NADH + H+
-
?
additional information specifically oxidizes L-lactaldehyde to L-lactate in presence of NAD+ Escherichia coli ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10.5 11
-
Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
9.2 11.2 pH 9.2: about 15% of maximum activity, pH 11.2: about 99% of maximum activity Escherichia coli

Cofactor

Cofactor Comment Organism Structure
additional information NADP+ can not substitute for NAD+ Escherichia coli
NAD+
-
Escherichia coli