Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxybenzaldehyde | - |
Rattus norvegicus | |
acetaldehyde | above 1 mM | Rattus norvegicus | |
AMP | 5'-AMP | Rattus norvegicus | |
NADH | competitive with respect to NAD+; mixed with respect to succinate semialdehyde | Rattus norvegicus | |
succinate semialdehyde | substrate inhibition, uncompetitive with respect to NAD+ | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0025 | - |
NAD+ | - |
Rattus norvegicus | |
0.0027 | 0.0029 | succinate semialdehyde | - |
Rattus norvegicus | |
0.03 | - |
NAD+ | - |
Rattus norvegicus | |
0.05 | - |
3-acetylpyridine adenine dinucleotide | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+ | compulsory-order mechanism, NAD+ is the first substrate to bind to the enzyme and NADH is the last product to dissociate from it | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.12 | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
-20°C, in presence of 10% v/v glycerol, stable for several months | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate semialdehyde + 3-acetylpyridine adenine dinucleotide + H2O | - |
Rattus norvegicus | succinate + reduced 3-acetylpyridine adenine dinucleotide + H+ | - |
r | |
succinate semialdehyde + NAD+ + H2O | - |
Rattus norvegicus | succinate + NADH | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 10 | pH 7.0: about 40% of maximal activity, pH 10.0: about 35% of maximal activity | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
3-acetylpyridine adenine dinucleotide | - |
Rattus norvegicus | |
NAD+ | - |
Rattus norvegicus |