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Literature summary for 1.2.1.24 extracted from
- Purification and properties of rat brain succinic semialdehyde dehydrogenase (1977), Biochimie, 59, 257-268.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxybenzaldehyde | - |
Rattus norvegicus |  |
| ADP | - |
Rattus norvegicus | |
| AMP | - |
Rattus norvegicus | |
| ATP | - |
Rattus norvegicus | |
| benzaldehyde | - |
Rattus norvegicus | |
| Chloral hydrate | - |
Rattus norvegicus | |
| iodoacetamide | - |
Rattus norvegicus | |
| p-bromobenzaldehyde | 1 mM, 38% inhibition | Rattus norvegicus | |
| p-chlorobenzaldehyde | 1 mM, 38% inhibition | Rattus norvegicus | |
| p-ethoxybenzaldehyde | 1 mM, 19% inhibition | Rattus norvegicus | |
| p-ethylbenzaldehyde | 1 mM, 51% inhibition | Rattus norvegicus | |
| p-fluorobenzaldehyde | 1 mM, 19% inhibition | Rattus norvegicus | |
| p-iodobenzaldehyde | 1 mM, 52% inhibition | Rattus norvegicus | |
| p-isopropylbenzaldehyde | 1 mM, 19% inhibition | Rattus norvegicus | |
| p-Methoxybenzaldehyde | 1 mM, 19% inhibition | Rattus norvegicus | |
| p-methylbenzaldehyde | 1 mM, 64% inhibition | Rattus norvegicus | |
| p-nitrobenzaldehyde | 1 mM, 20% inhibition | Rattus norvegicus | |
| succinate semialdehyde | - |
Rattus norvegicus | |
| Valeraldehyde | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
NAD+ | - |
Rattus norvegicus | |
| 0.1 | - |
succinate semialdehyde | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 68000 | - |
2 * 68000, SDS-PAGE | Rattus norvegicus |
| 140000 | - |
gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+ | compulsory ordered mechanism where NAD+ binds first followed by succinate semialdehyde | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 27 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate semialdehyde + NAD+ + H2O | reverse reaction proceeds at 1/1230 of the rate of the forward eaction | Rattus norvegicus | succinate + NADH | - |
ir | |
| succinate semialdehyde + NADP+ + H2O | reaction with NADP+ is 13% of the activity with NAD+ | Rattus norvegicus | succinate + NADPH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 68000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.6 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 10 | about 50% of maximal activity at pH 7.0 and at pH 10.0 | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Rattus norvegicus | |
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