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Literature summary for 1.2.1.24 extracted from

  • Hujber, Z.; Horvath, G.; Petoevari, G.; Krencz, I.; Danko, T.; Meszaros, K.; Rajnai, H.; Szoboszlai, N.; Leenders, W.P.J.; Jeney, A.; Tretter, L.; Sebestyen, A.
    GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas (2018), J. Exp. Clin. Cancer Res., 37, 271 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.24

Application

Application Comment Organism
medicine GABA oxidation and SSADH activity might be additional therapeutic targets in gliomas/glioblastomas Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate semialdehyde + NAD+ + H2O Homo sapiens
-
 succinate + NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P51649
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Homo sapiens
-
astrocytoma cell
-
 Homo sapiens
-
glioma cell astrocytomas and oligodendrogliomas Homo sapiens
-
additional information no expression of enzyme SSADH in U-87MG and U-373MG cells Homo sapiens
-
oligodendrocyte
-
 Homo sapiens
-
oligodendroglioma cell
-
 Homo sapiens
-
U-251MG cell glioma cells, SSADH protein level differences in IDH1m and 2-HG-treated U251 wild-type cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate semialdehyde + NAD+ + H2O
-
 Homo sapiens succinate + NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
SSADH
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction GABA addition to glioma cells increased proliferation rates. Expression of mutated IDH1 and treatment with 2-HG reduced glutamine and GABA oxidation, diminishes the pro-proliferative effect of GABA in succinic semialdehyde dehydrogenase (SSADH) expressing cells. The enzyme SSADH is overexpressed in almost all glioma cells. No significant association between SSADH expression and clinicopathological parameters (e.g. IDH mutation). IDH mutation and 2-HG production inhibit GABA oxidation in glioma cells Homo sapiens
metabolism astrocytomas and oligodendrogliomas, collectively called diffuse gliomas, are derived from astrocytes and oligodendrocytes that are in metabolic symbiosis with neurons. Astrocytes can catabolize neuron-derived glutamate and gamma-aminobutyric acid (GABA) for supporting and regulating neuronal functions. Succinic semialdehyde dehydrogenase (SSADH) expression is correlated to GABA oxidation. SSADH expression may participate in the oxidation and/or consumption of GABA in gliomas, furthermore, GABA oxidation capacity may contribute to proliferation and worse prognosis of gliomas Homo sapiens
physiological function GABA can feed the TCA cycle via the activities of GABA transaminase and succinic semialdehyde dehydrogenase (SSADH) to produce succinate. Potential role of GABA shunt and SSADH activity in the survival and the proliferation of SSADH expressing U-251 wild-type cells Homo sapiens