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Literature summary for 1.2.1.3 extracted from

  • Missihoun, T.; Kotchoni, S.; Bartels, D.
    Aldehyde dehydrogenases function in the homeostasis of pyridine nucleotides in Arabidopsis thaliana (2018), Sci. Rep., 8, 2936 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.3

Protein Variants

Protein Variants Comment Organism
additional information construction of a single ALDH3I1 mutant K06 line and a double T-DNA insertion mutant line K06/62 that is defective in representative members of Arabidopsis thaliana ALDH families 3 and 7, ALDH3I1 and ALDH7B4, by T-DNA insertion. The loss of function of ALDH3I1 and ALDH7B4 leads to a decrease of NAD(P)H, NAD(P)H/NAD(P) ratio, and an alteration of the glutathione pools. The aldh double mutant has higher glucose-6-phosphate dehydrogenase activity than the wild-type, indicating a high demand for reduced pyridine nucleotides. Mutant KO6 plants accumulate higher levels of reactive oxygen species (ROS) and malondialdehyde (MDA) than the wild-type. Moreover, the mutant has a reduced quantum yield of photosystem II and photosynthetic capacity at relatively high light intensities compared to the wild-type. The levels of the total glutathione (reduced + oxidized) and of the reduced to oxidized glutathione ratio (GSH/GSSG) are reduced by 20% and 33% in KO6/62 compared to wild-type, respectively. Phenotype, overview Arabidopsis thaliana
additional information construction of of a single ALDH7B4 mutant K62 line and a double T-DNA insertion mutant that is defective in representative members of Arabidopsis thaliana ALDH families 3and 7, ALDH3I1 and ALDH7B4, respectively. The loss of function of ALDH3I1 and ALDH7B4 leads to a decrease of NAD(P)H, NAD(P)H/NAD(P) ratio, and an alteration of the glutathione pools. The aldh double mutant has higher glucose-6-phosphate dehydrogenase activity than the wild-type, indicating a high demand for reduced pyridine nucleotides. Mutant K62 plants accumulate higher levels of reactive oxygen species (ROS) and malondialdehyde (MDA) than the wild-type. Moreover, the mutant has a reduced quantum yield of photosystem II and photosynthetic capacity at relatively high light intensities compared to the wild-type. The levels of the total glutathione (reduced + oxidized) and of the reduced to oxidized glutathione ratio (GSH/GSSG) are reduced by 20% and 33% in KO6/62 compared to wild-type, respectively. Phenotype, overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-
cytosol
-
 Arabidopsis thaliana 5829
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q8W033
-
-
Arabidopsis thaliana Q9SYG7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Arabidopsis thaliana
-
seedling
-
 Arabidopsis thaliana
-

Synonyms

Synonyms Comment Organism
ALDH3I1
-
 Arabidopsis thaliana
ALDH7B4
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana stress-triggered induction of ALDH3I1 up
Arabidopsis thaliana stress-triggered induction of ALDH7B4 up

General Information

General Information Comment Organism
evolution the enzyme is a member of Arabidopsis thaliana ALDH family 3 Arabidopsis thaliana
evolution the enzyme is a member of Arabidopsis thaliana ALDH family 7 Arabidopsis thaliana
malfunction the combined disruption of ALDH3I1 and ALDH7B4 decreases the cellular NAD(P)H contents and alters the NAD(P)H/NAD(P)+ ratio. The aldh double mutant has higher glucose-6-phosphate dehydrogenase activity and a reduced quantum yield of photosystem II and photosynthetic capacity at relatively high light intensities compared to the wild-type. Mutant KO6 plants accumulate higher levels of reactive oxygen species (ROS) and malondialdehyde (MDA) than the wild-type plants. Disruption of ALDH3I1 and ALDH7B4 affects glutathione metabolism and photosynthesis Arabidopsis thaliana
physiological function role of ALDHs as major contributors to the homeostasis of pyridine nucleotides in plants Arabidopsis thaliana