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Literature summary for 1.2.1.31 extracted from
- Inhibition of alpha-aminoadipate-semialdehyde dehydrogenase from Trichosporon adeninovorans by lysine and lysine analogues (1990), FEMS Microbiol. Lett., 70, 41-44.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| delta-hydroxylysine | competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH | Blastobotrys adeninivorans |  |
| L-lysine | competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH | Blastobotrys adeninivorans | |
| S-(beta-aminoethyl)-L-cysteine | competitive with respect to alpha-aminoadipate, non-competitive with respect to both ATP and NADPH | Blastobotrys adeninivorans | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.23 | - |
NADPH | - |
Blastobotrys adeninivorans | |
| 0.77 | - |
MgCl2 | - |
Blastobotrys adeninivorans | |
| 0.78 | - |
alpha-aminoadipate | - |
Blastobotrys adeninivorans | |
| 1 | - |
ATP | - |
Blastobotrys adeninivorans | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for activity | Blastobotrys adeninivorans | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alpha-aminoadipate + NAD(P)H | Blastobotrys adeninivorans | in presence of ATP and Mg2+ | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
| L-alpha-aminoadipate + NAD(P)H | Blastobotrys adeninivorans | sixth step of lysine biosynthesis | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Blastobotrys adeninivorans | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| using DEAE-cellulose column chromatography | Blastobotrys adeninivorans |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Blastobotrys adeninivorans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-aminoadipic semialdehyde + NAD+ + H2O | - |
Blastobotrys adeninivorans | alpha-aminoadipic acid + NADH + H+ | - |
? | |
| L-2-aminoadipate + NADPH | in presence of ATP + Mg2+ | Blastobotrys adeninivorans | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
| L-alpha-aminoadipate + NAD(P)H | in presence of ATP and Mg2+ | Blastobotrys adeninivorans | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
| L-alpha-aminoadipate + NAD(P)H | sixth step of lysine biosynthesis | Blastobotrys adeninivorans | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.7 | - |
Blastobotrys adeninivorans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Blastobotrys adeninivorans | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.007 | - |
S-(beta-aminoethyl)-L-cysteine | - |
Blastobotrys adeninivorans | |
| 0.09 | - |
L-lysine | - |
Blastobotrys adeninivorans | |
| 1.65 | - |
delta-hydroxylysine | - |
Blastobotrys adeninivorans | |
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