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Literature summary for 1.2.1.36 extracted from
- Enzymic characteristics of retinal dehydrogenase type I expressed in Escherichia coli (1997), Biochim. Biophys. Acta, 1342, 175-181.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| CRBP | enzyme recognizes retinal as substrate in presence of CRBP | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| apo-CRBP | IC50 0.0014 mM | Rattus norvegicus | |
| citral | IC50 about 0.001 mM | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0003 | - |
benzaldehyde | - |
Rattus norvegicus | |
| 0.0003 | - |
hexanal | - |
Rattus norvegicus | |
| 0.0003 | - |
decanal | - |
Rattus norvegicus | |
| 0.0003 | - |
octanal | - |
Rattus norvegicus | |
| 0.0017 | - |
all-trans-retinal | - |
Rattus norvegicus | |
| 0.0066 | - |
propanal | - |
Rattus norvegicus | |
| 0.022 | - |
NAD+ | standard deviation 0.004 mM | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| retinal + NAD+ + H2O | Rattus norvegicus | - |
retinoate + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, 20 mM Hepes, 2 mM DTT, 150 mM KCl, 15% glycerol, pH 8 | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzaldehyde + NAD+ + H2O | - |
Rattus norvegicus | benzoate + NADH + H+ | - |
? | |
| decanal + NAD+ + H2O | - |
Rattus norvegicus | decanoic acid + NADH | - |
? | |
| hexanal + NAD+ + H2O | - |
Rattus norvegicus | hexanoate + NADH + H+ | - |
? | |
| octanal + NAD+ + H2O | - |
Rattus norvegicus | octanoate + NADH | - |
? | |
| propanal + NAD+ + H2O | - |
Rattus norvegicus | propanoate + NADH + H+ | - |
? | |
| retinal + NAD+ + H2O | - |
Rattus norvegicus | retinoate + NADH | - |
? | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 9 | exhibits a broad pH optimum | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | reaction is NAD+ dependent, rather than NADP+ dependent | Rattus norvegicus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
IC50 about 0.001 mM | Rattus norvegicus | citral | |
| 0.0014 | - |
IC50 0.0014 mM | Rattus norvegicus | apo-CRBP |
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