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Literature summary for 1.2.1.36 extracted from

  • Mey, J.; Babiuk, R.P.; Clugston, R.; Zhang, W.; Greer, J.J.
    Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents (2003), Am. J. Pathol., 162, 673-679.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
4-biphenyl carboxylic acid 90% inhibition at 0.1 mM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo Rattus norvegicus
N,N'-octamethylenebis (dichloroacetamide) complete inhibition at very low concentration below 1 pM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo Rattus norvegicus
nitrofen 90% inhibition at 0.1 mM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo Rattus norvegicus
SB-210661 80% inhibition at 1 mM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
all-trans-retinal + NAD+ + H2O Rattus norvegicus key enzyme in retinoic acid biosynthesis, essential in developing diaphragm, enzyme inhibition or disfunction causes the serious developmental anomaly congenital diaphragmatic hernia, i.e. CDH all-trans-retinoic acid + NADH
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
18-days-pregnant Sprague-Dawley rats
-

Purification (Commentary)

Purification (Comment) Organism
partially by isoelectric focusing Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
diaphragm
-
Rattus norvegicus
-
oligodendrocyte cell culture Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-retinal + NAD+ + H2O
-
Rattus norvegicus all-trans-retinoic acid + NADH
-
?
all-trans-retinal + NAD+ + H2O key enzyme in retinoic acid biosynthesis, essential in developing diaphragm, enzyme inhibition or disfunction causes the serious developmental anomaly congenital diaphragmatic hernia, i.e. CDH Rattus norvegicus all-trans-retinoic acid + NADH
-
?

Synonyms

Synonyms Comment Organism
RALDH2
-
Rattus norvegicus
retinal dehydrogenase-2
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus