Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-biphenyl carboxylic acid | 90% inhibition at 0.1 mM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo | Rattus norvegicus | |
N,N'-octamethylenebis (dichloroacetamide) | complete inhibition at very low concentration below 1 pM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo | Rattus norvegicus | |
nitrofen | 90% inhibition at 0.1 mM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo | Rattus norvegicus | |
SB-210661 | 80% inhibition at 1 mM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinal + NAD+ + H2O | Rattus norvegicus | key enzyme in retinoic acid biosynthesis, essential in developing diaphragm, enzyme inhibition or disfunction causes the serious developmental anomaly congenital diaphragmatic hernia, i.e. CDH | all-trans-retinoic acid + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
18-days-pregnant Sprague-Dawley rats | - |
Purification (Comment) | Organism |
---|---|
partially by isoelectric focusing | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
diaphragm | - |
Rattus norvegicus | - |
oligodendrocyte | cell culture | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinal + NAD+ + H2O | - |
Rattus norvegicus | all-trans-retinoic acid + NADH | - |
? | |
all-trans-retinal + NAD+ + H2O | key enzyme in retinoic acid biosynthesis, essential in developing diaphragm, enzyme inhibition or disfunction causes the serious developmental anomaly congenital diaphragmatic hernia, i.e. CDH | Rattus norvegicus | all-trans-retinoic acid + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RALDH2 | - |
Rattus norvegicus |
retinal dehydrogenase-2 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus |