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Literature summary for 1.2.1.36 extracted from

  • Thangavelu, G.; Lee, Y.C.; Loschi, M.; Schaechter, K.M.; Feser, C.J.; Koehn, B.H.; Nowak, E.C.; Zeiser, R.; Serody, J.S.; Murphy, W.J.; Munn, D.H.; Chambon, P.; Noelle, R.J.; Blazar, B.R.
    Dendritic cell expression of retinal aldehyde dehydrogenase-2 controls graft-versus-host disease lethality (2019), J. Immunol., 202, 2795-2805 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
retinal + NAD+ + H2O Mus musculus
-
 retinoate + NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell isoform RALDH2 is dominantly expressed in dendritic cells Mus musculus
-
intestinal epithelial cell isoform RALDH1 is dominantly expressed in intestinal epithelial cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
retinal + NAD+ + H2O
-
 Mus musculus retinoate + NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
RalDH1 isoform Mus musculus
RALDH2 isoform Mus musculus
retinaldehyde dehydrogenase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus

General Information

General Information Comment Organism
malfunction ablation of retinoic acid signaling in host dencritic cells by deletion of isoform RALDH2 protects mice from acute graft-versus-host disease. Isoform RALDH1 deletion fails to reduce acute graft-versus-host disease Mus musculus
physiological function isoform RALDH2 expression in dendritic cells is critical to control acute graft-versus-host disease lethality Mus musculus