Activating Compound | Comment | Organism | Structure |
---|---|---|---|
7-(2-oxopropoxy)-2H-1-benzopyran-2-one | activates by 6% at 0.01 mM | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
purified enzyme in complex with inhibitors 2,3,5-trimethyl-6-[3-oxo-3-(piperidin-1-yl)propyl]-7H-furo[3,2-g][1]benzopyran-7-one, 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one, and 3-benzyl-4-methyl-2-oxo-2H-1-benzopyran-7-yl methanesulfonate, X-ray diffraction structure determination and analysis at 1.70-2.05 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3,5,6,9-pentamethyl-7H-furo[3,2-g][1]benzopyran-7-one | 21.6% inhibition at 0.01 mM | Homo sapiens | |
2,3,5,6-tetramethyl-7H-furo[3,2-g][1]benzopyran-7-one | 9.5% inhibition at 0.01 mM | Homo sapiens | |
2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one | 63.7% inhibition at 0.01 mM | Homo sapiens | |
2,3,5-trimethyl-6-[3-oxo-3-(piperidin-1-yl)propyl]-7H-furo[3,2-g][1]benzopyran-7-one | 91.3% inhibition at 0.01 mM | Homo sapiens | |
2,3-dimethyl-5-propyl-7H-furo[3,2-g][1]benzopyran-7-one | 25.9% inhibition at 0.01 mM | Homo sapiens | |
2-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]-N-phenylacetamide | 50.4% inhibition at 0.01 mM | Homo sapiens | |
2-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetamide | 71.5% inhibition at 0.01 mM | Homo sapiens | |
2H-furo[2,3-h][1]benzopyran-2-one | 39.0% inhibition at 0.01 mM | Homo sapiens | |
3,4,10-trimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-2,6-dione | 32.6% inhibition at 0.01 mM | Homo sapiens | |
3,4,8,9-tetramethyl-7H-furo[2,3-f][1]benzopyran-7-one | 38.5% inhibition at 0.01 mM | Homo sapiens | |
3,4-dimethyl-6,7,8,9-tetrahydro-2H-[1]benzofuro[3,2-g][1]benzopyran-2-one | 35.7% inhibition at 0.01 mM | Homo sapiens | |
3,5-dimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one | 51.4% inhibition at 0.01 mM | Homo sapiens | |
3-benzyl-4-methyl-2-oxo-2H-1-benzopyran-7-yl methanesulfonate | 75.4% inhibition at 0.01 mM | Homo sapiens | |
3-tert-butyl-5,6-dimethyl-7H-furo[3,2-g][1]benzopyran-7-one | 5.5% inhibition at 0.01 mM | Homo sapiens | |
3-[(3-oxobutan-2-yl)oxy]-6H-dibenzo[b,d]pyran-6-one | 41.3% inhibition at 0.01 mM | Homo sapiens | |
4-methyl-7-(2-oxo-2-phenylethoxy)-2H-1-benzopyran-2-one | 71.0% inhibition at 0.01 mM | Homo sapiens | |
4-methyl-7-(2-oxopropoxy)-2H-1-benzopyran-2-one | 47.8% inhibition at 0.01 mM | Homo sapiens | |
4-methyl-7-[(3-methylbut-2-en-1-yl)oxy]-2H-1-benzopyran-2-one | 61.7% inhibition at 0.01 mM | Homo sapiens | |
4-methyl-7-[(prop-2-en-1-yl)oxy]-2H-1-benzopyran-2-one | 64.5% inhibition at 0.01 mM | Homo sapiens | |
5-benzyl-2,3-dimethyl-7H-furo[3,2-g][1]benzopyran-7-one | 43.0% inhibition at 0.01 mM | Homo sapiens | |
5-methyl-2-[(3-oxobutan-2-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one | 31.3% inhibition at 0.01 mM | Homo sapiens | |
6-benzyl-3,5-dimethyl-7H-furo[3,2-g][1]benzopyran-7-one | 12.6% inhibition at 0.01 mM; 41.5% inhibition at 0.01 mM | Homo sapiens | |
6-bromo-3-[(1E)-N-hydroxyethanimidoyl]-2H-1-benzopyran-2-one | - |
Homo sapiens | |
6-methyl-3,4-dihydro-2H,8H-benzo[1,2-b:5,4-b']dipyran-2,8-dione | 34.8% inhibition at 0.01 mM | Homo sapiens | |
7-(2-oxopropoxy)-2H-1-benzopyran-2-one | 7.6% inhibition at 0.01 mM | Homo sapiens | |
7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one | 85.7% inhibition at 0.01 mM | Homo sapiens | |
7-methoxy-4-methyl-2H-1-benzopyran-2-one | 19.8% inhibition at 0.01 mM | Homo sapiens | |
8,9-dimethyl-2,3-dihydrocyclopenta[c]furo[3,2-g][1]benzopyran-4(1H)-one | 49.2% inhibition at 0.01 mM | Homo sapiens | |
9,10-dimethyl-1,2,3,4-tetrahydro-5H-6,8-dioxacyclopenta[b]phenanthren-5-one | 43.7% inhibition at 0.01 mM | Homo sapiens | |
9,10-dimethyl-5H-6,8-dioxacyclopenta[b]phenanthren-5-one | 17.6% inhibition at 0.01 mM | Homo sapiens | |
daidzin | - |
Homo sapiens | |
additional information | inhibition of the aldehyde dehydrogenase 1/2 family by psoralen and coumarin derivatives, structure-function relationships, overview. Poor or no inhibition by daidzin, methyl 2-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]propanoate, 2-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]propanoic acid, 3-(7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-3-yl)propanoic acid, and 6-bromo-3-[(1E)-N-hydroxyethanimidoyl]-2H-1-benzopyran-2-one; inhibition of the aldehyde dehydrogenase 1/2 family by psoralen and coumarin derivatives, structure-function relationships, overview. Poor or no inhibition by daidzin, methyl 2-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]propanoate, 9,10-dimethyl-1,2,3,4-tetrahydro-5H-6,8-dioxacyclopenta[b]phenanthren-5-one, and 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one; inhibition of the aldehyde dehydrogenase 1/2 family by psoralen and coumarin derivatives, structure-function relationships, overview. Poor or no inhibition by methyl 2-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]propanoate, 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one, and 6-bromo-3-[(1E)-N-hydroxyethanimidoyl]-2H-1-benzopyran-2-one | Homo sapiens | |
N-(4,7-dimethyl-2-oxo-2H-1-benzopyran-6-yl)-2-methylpropanamide | 40.2% inhibition at 0.01 mM | Homo sapiens | |
N-benzyl-3-(2,3,5-trimethyl-7-oxo-7H-furo[3,2-g][1]benzopyran-6-yl)propanamide | 6.4% inhibition at 0.01 mM | Homo sapiens | |
[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetonitrile | 64.3% inhibition at 0.01 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinal + H2O + NAD+ | Homo sapiens | - |
all-trans-retinoate + NADH + 2 H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O94788 | - |
- |
Homo sapiens | P00352 | - |
- |
Homo sapiens | P47895 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinal + H2O + NAD+ | - |
Homo sapiens | all-trans-retinoate + NADH + 2 H+ | - |
? | |
propionaldehyde + NAD+ | - |
Homo sapiens | propionate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALDH1A1 | - |
Homo sapiens |
Aldh1a2 | - |
Homo sapiens |
Aldh1a3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000065 | - |
pH 7.5, 25°C | Homo sapiens | 9,10-dimethyl-1,2,3,4-tetrahydro-5H-6,8-dioxacyclopenta[b]phenanthren-5-one | |
0.000069 | - |
pH 7.5, 25°C | Homo sapiens | 2,3-dimethyl-5-propyl-7H-furo[3,2-g][1]benzopyran-7-one | |
0.00013 | - |
pH 7.5, 25°C | Homo sapiens | 2,3,5-trimethyl-6-[3-oxo-3-(piperidin-1-yl)propyl]-7H-furo[3,2-g][1]benzopyran-7-one | |
0.00013 | - |
pH 7.5, 25°C | Homo sapiens | 8,9-dimethyl-2,3-dihydrocyclopenta[c]furo[3,2-g][1]benzopyran-4(1H)-one | |
0.00013 | - |
pH 7.5, 25°C | Homo sapiens | 9,10-dimethyl-1,2,3,4-tetrahydro-5H-6,8-dioxacyclopenta[b]phenanthren-5-one | |
0.00017 | - |
pH 7.5, 25°C | Homo sapiens | 8,9-dimethyl-2,3-dihydrocyclopenta[c]furo[3,2-g][1]benzopyran-4(1H)-one | |
0.00027 | - |
pH 7.5, 25°C | Homo sapiens | 2,3,5,6-tetramethyl-7H-furo[3,2-g][1]benzopyran-7-one | |
0.0003 | - |
pH 7.5, 25°C | Homo sapiens | 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one | |
0.00033 | - |
pH 7.5, 25°C | Homo sapiens | 2,3,5,6-tetramethyl-7H-furo[3,2-g][1]benzopyran-7-one | |
0.0004 | - |
pH 7.5, 25°C | Homo sapiens | 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one | |
0.00076 | - |
pH 7.5, 25°C | Homo sapiens | 3,5-dimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one | |
0.0011 | - |
pH 7.5, 25°C | Homo sapiens | 3,5-dimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one | |
0.0016 | - |
pH 7.5, 25°C | Homo sapiens | 2,3,5-trimethyl-6-[3-oxo-3-(piperidin-1-yl)propyl]-7H-furo[3,2-g][1]benzopyran-7-one | |
0.0045 | - |
pH 7.5, 25°C | Homo sapiens | daidzin | |
0.01 | - |
pH 7.5, 25°C | Homo sapiens | 3-benzyl-4-methyl-2-oxo-2H-1-benzopyran-7-yl methanesulfonate | |
0.011 | - |
pH 7.5, 25°C | Homo sapiens | 3-benzyl-4-methyl-2-oxo-2H-1-benzopyran-7-yl methanesulfonate | |
0.014 | - |
pH 7.5, 25°C | Homo sapiens | 2,3,5-trimethyl-6-[3-oxo-3-(piperidin-1-yl)propyl]-7H-furo[3,2-g][1]benzopyran-7-one |