BRENDA - Enzyme Database
show all sequences of 1.2.1.4

Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice

Lassen, N.; Bateman, J.B.; Estey, T.; Kuszak, J.R.; Nees, D.W.; Piatigorsky, J.; Duester, G.; Day, B.J.; Huang, J.; Hines, L.M.; Vasiliou, V.; J. Biol. Chem. 282, 25668-25676 (2007)

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
51000
-
SDS-PAGE
Mus musculus
Organism
Organism
UniProt
Commentary
Textmining
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cornea
-
Mus musculus
-
additional information
undetectable in the lens
Mus musculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.853
-
wild type enzyme from cornea, using propionaldehyde and NAD+ as substrates
Mus musculus
3.43
-
wild type enzyme from cornea, using NADP+ and benzaldehyde as substrates
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
4-hydroxy-2-nonenal + NADP+
-
687599
Mus musculus
(2E)-4-hydroxynon-2-enoate + NADPH + H+
-
-
-
?
benzaldehyde + NADP+
-
687599
Mus musculus
benzoate + NADPH + H+
-
-
-
?
malondialdehyde + NADP+
poor substrate
687599
Mus musculus
?
-
-
-
?
propionaldehyde + NADP+
poor substrate
687599
Mus musculus
propionate + NADPH + H+
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
aldehyde dehydrogenase 3A1
-
Mus musculus
ALDH3A1
-
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Mus musculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
51000
-
SDS-PAGE
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cornea
-
Mus musculus
-
additional information
undetectable in the lens
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.853
-
wild type enzyme from cornea, using propionaldehyde and NAD+ as substrates
Mus musculus
3.43
-
wild type enzyme from cornea, using NADP+ and benzaldehyde as substrates
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
4-hydroxy-2-nonenal + NADP+
-
687599
Mus musculus
(2E)-4-hydroxynon-2-enoate + NADPH + H+
-
-
-
?
benzaldehyde + NADP+
-
687599
Mus musculus
benzoate + NADPH + H+
-
-
-
?
malondialdehyde + NADP+
poor substrate
687599
Mus musculus
?
-
-
-
?
propionaldehyde + NADP+
poor substrate
687599
Mus musculus
propionate + NADPH + H+
-
-
-
?
Other publictions for EC 1.2.1.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739966
Bezsudnova
NADP-dependent aldehyde dehydr ...
Pyrobaculum ferrireducens, Pyrobaculum ferrireducens 1860
Archaea
2016
9127857
2016
-
-
1
1
-
-
-
3
-
-
-
-
-
4
-
-
1
-
-
-
-
-
8
-
2
1
1
-
3
-
1
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
3
-
-
-
-
-
-
-
1
-
-
-
-
8
-
1
1
-
3
-
1
-
-
-
-
-
-
3
3
723749
Mihasan
Evidence of a plasmid-encoded ...
Paenarthrobacter nicotinovorans
Res. Microbiol.
164
22-30
2013
-
-
1
-
-
-
-
9
-
-
-
-
-
1
-
-
-
-
-
-
-
-
8
-
1
-
-
-
9
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
9
-
-
-
-
-
-
-
-
9
9
724459
Mukhopadhyay
Mitochondrial NAD dependent al ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
1830
3391-3398
2013
-
-
1
-
2
-
-
-
5
-
-
1
-
5
-
-
1
-
-
-
6
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
5
-
-
1
-
-
-
1
-
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712174
Alka
Substrate profiling and aldehy ...
Rattus norvegicus
Int. J. Biochem. Cell Biol.
42
2012-2018
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
17
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688781
Patel
ALDH1A1 and ALDH3A1 expression ...
Homo sapiens
Lung Cancer
59
340-349
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
5
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673477
Estey
ALDH3A1: a corneal crystallin ...
Oryctolagus cuniculus, Homo sapiens, Mammalia, Mus musculus
Exp. Eye Res.
84
3-12
2007
-
4
-
-
-
-
4
20
4
-
-
4
-
4
-
-
-
-
-
5
-
-
20
-
12
-
-
-
-
-
-
-
4
-
-
-
-
4
-
4
-
-
-
-
4
-
20
4
-
-
4
-
-
-
-
-
5
-
-
20
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687599
Lassen
Multiple and additive function ...
Mus musculus
J. Biol. Chem.
282
25668-25676
2007
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
2
-
4
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
2
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677193
Short
Metabolism of trans, trans-muc ...
Mus musculus
Toxicol. Appl. Pharmacol.
210
163-170
2006
-
-
1
-
-
-
-
1
-
-
1
1
-
1
-
-
1
-
-
1
-
-
2
-
3
1
-
-
-
1
-
-
1
-
1
-
-
-
1
1
-
-
-
-
-
-
1
-
-
1
1
-
-
-
1
-
1
-
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
655889
Ho
Isolation and characterization ...
Escherichia coli
J. Bacteriol.
187
1067-1073
2005
1
-
1
-
1
-
-
6
-
1
3
2
-
1
-
-
1
-
-
-
1
-
8
1
-
-
-
-
-
1
-
-
2
-
-
-
1
-
1
2
-
1
-
-
-
-
6
-
1
3
2
-
-
-
1
-
-
1
-
8
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
437840
Dickinson
The purification and some prop ...
Saccharomyces cerevisiae
Biochem. J.
315
393-399
1996
-
-
-
-
-
-
2
-
1
1
2
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
1
1
2
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
437829
Hommel
-
NADP+-dependent aldehyde dehyd ...
Acetobacter pasteurianus, Acetobacter pasteurianus CCM 1774
J. Basic Microbiol.
28
25-33
1988
-
-
-
-
-
-
6
5
1
-
1
2
-
2
-
-
1
1
-
-
1
1
10
-
-
-
-
-
-
1
1
1
1
1
-
-
-
-
-
1
-
-
-
-
6
1
5
1
-
1
2
-
-
-
1
-
-
1
1
10
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
437830
Aurich
Kinetics of membrane-bound ald ...
Acinetobacter calcoaceticus
Biol. Chem. Hoppe-Seyler
368
101-109
1987
1
-
-
-
-
-
17
14
2
-
-
1
-
3
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
1
1
-
1
9
-
-
1
-
-
1
-
-
-
-
17
9
14
2
-
-
1
-
-
-
-
-
-
-
-
8
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
437831
Aurich
-
Wechselwirkungen der Aldehydde ...
Acinetobacter calcoaceticus
J. Basic Microbiol.
25
623-629
1985
-
-
-
-
-
-
3
1
1
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
1
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437832
Aurich
-
Wechselwirkungen der Aldehydde ...
Acinetobacter calcoaceticus
J. Basic Microbiol.
25
631-636
1985
-
-
-
-
-
-
1
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348681
Vandecasteele
Aldehyde dehydrogenases from P ...
Pseudomonas aeruginosa
Methods Enzymol.
89
484-490
1982
-
-
-
-
-
-
-
5
-
-
1
-
-
1
-
-
1
-
-
-
-
1
5
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
5
-
-
1
-
-
-
-
1
-
-
-
1
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437833
Sasaki
Aldehyde dehydrogenase from Pr ...
Proteus vulgaris
Methods Enzymol.
89
480-483
1982
1
-
-
1
-
-
-
4
-
2
1
-
-
1
-
-
1
-
-
-
1
-
4
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
1
-
-
-
-
-
4
-
2
1
-
-
-
-
1
-
-
1
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
437834
Muraoka
-
Purification and properties of ...
Acetobacter aceti
J. Ferment. Technol.
58
501-507
1980
-
-
-
-
-
-
11
-
-
3
5
-
-
1
-
-
1
-
-
-
-
-
10
5
-
-
-
2
-
-
-
1
1
-
-
-
-
-
-
1
-
-
-
-
11
-
-
-
3
5
-
-
-
-
1
-
-
-
-
10
5
-
-
2
-
-
-
1
-
-
-
-
-
-
-
437835
Adachi
-
Crystallization and properties ...
Acetobacter aceti, Acetobacter acetigenus, Acetobacter orleanensis, Acetobacter ascendens, Frateuria aurantia, Gluconobacter oxydans, Acetobacter pasteurianus, Gluconobacter albidus, Gluconobacter cerinus, Gluconobacter gluconicus, Gluconacetobacter liquefaciens, Gluconobacter roseus, Gluconobacter sphaericus
Agric. Biol. Chem.
44
155-164
1980
-
-
-
1
-
-
8
2
-
4
2
12
-
21
-
-
1
-
-
-
1
-
35
1
-
1
-
-
-
1
-
1
14
-
-
-
-
-
-
14
1
-
-
-
8
-
2
-
4
2
12
-
-
-
1
-
-
1
-
35
1
1
-
-
-
1
-
1
-
-
-
-
-
-
-
348725
Guerrillot
Purification and characterizat ...
Pseudomonas aeruginosa
Eur. J. Biochem.
81
185-192
1977
-
-
-
-
-
-
3
15
-
1
1
-
-
1
-
-
1
-
-
-
1
1
14
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
15
-
1
1
-
-
-
-
1
-
-
1
1
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437836
Sugawara
Purification and properties of ...
Proteus vulgaris
Biochim. Biophys. Acta
480
343-350
1977
2
-
-
1
-
-
-
3
-
2
1
-
-
6
-
-
1
-
-
-
1
-
4
-
-
-
-
-
-
1
-
-
1
-
-
-
2
-
-
1
1
-
-
-
-
-
3
-
2
1
-
-
-
-
1
-
-
1
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
437839
Jacobson
Mitochondrial acetaldehyde deh ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
350
277-291
1974
-
-
-
-
-
-
-
-
1
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437838
Seegmiller
Triphosphopyridine nucleotide- ...
Saccharomyces cerevisiae
J. Biol. Chem.
201
629-637
1953
-
-
-
-
-
-
-
3
-
4
-
-
-
1
-
-
1
-
-
-
1
-
4
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
4
-
-
-
-
-
1
-
-
1
-
4
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-