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Literature summary for 1.2.1.44 extracted from

  • Van Acker, R.; Leple, J.C.; Aerts, D.; Storme, V.; Goeminne, G.; Ivens, B.; Legee, F.; Lapierre, C.; Piens, K.; Van Montagu, M.C.; Santoro, N.; Foster, C.E.; Ralph, J.; Soetaert, W.; Pilate, G.; Boerjan, W.
    Improved saccharification and ethanol yield from field-grown transgenic poplar deficient in cinnamoyl-CoA reductase (2014), Proc. Natl. Acad. Sci. USA, 111, 845-850 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
biotechnology CCR downregulation may become a successful strategy to improve biomass processing if the variability in down-regulation and the yield penalty can be overcome Populus tremula x Populus alba

Protein Variants

Protein Variants Comment Organism
additional information construction of genetically modified poplars, that are downregulated for cinnamoyl-CoA reductase (CCR). 20 month-old trees transgenic trees with downregulated CCR enzymes show up to 161% increased ethanol yield from tissues including bark, generated from the lignocellulosic biomass, strong downregulation of CCR also affects biomass yield. Wood samples derived from the transgenic trees are more easily processed into ethanol than wild-type Populus tremula x Populus alba

Organism

Organism UniProt Comment Textmining
Populus tremula x Populus alba
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General Information

General Information Comment Organism
malfunction 20 month-old trees transgenic trees with downregulated CCR enzymes show up to 161% increased ethanol yield from tissues including bark, generated from the lignocellulosic biomass, strong downregulation of CCR also affects biomass yield. Wood samples derived from the transgenic trees are more easily processed into ethanol than wild-type. The improved saccharification yield is due to a higher cellulose conversion and correlates with the abundance of ferulic acid markers Populus tremula x Populus alba
metabolism enzyme cinnamoyl-CoA reductase (CCR) catalyzes the first step in the monolignol-specific branch of the lignin biosynthetic pathway Populus tremula x Populus alba