Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lipid droplet | - |
Mus musculus | 5811 | - |
additional information | the C-terminal regions, particularly the two tryptophan residues (Trp462 and Trp469) of isozyme ALDH3B2 and the two arginine residues (Arg462 and Arg463) of isozyme ALDH3B3, are important for the determination of their specific localization | Mus musculus | - |
- |
plasma membrane | - |
Mus musculus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | E9Q3E1 | - |
- |
Mus musculus | J3QMK6 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
lipoprotein | enzyme ALDH3B2 is modified by prenylation at its C-terminus. The modification greatly influences its membrane localization and enzymatic activity towards hexadecanal | Mus musculus |
lipoprotein | enzyme ALDH3B3 is modified by prenylation at its C-terminus. The modification greatly influences its membrane localization and enzymatic activity towards hexadecanal | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hexadecanal + NAD+ + H2O | - |
Mus musculus | hexadecanoate + NADH + 2 H+ | - |
? | |
additional information | the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes | Mus musculus | ? | - |
? | |
additional information | the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALDH3B2 | - |
Mus musculus |
ALDH3B3 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme is a member of the ALDH3 family | Mus musculus |
physiological function | ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) are responsible for the removal of lipid-derived aldehydes | Mus musculus |
physiological function | ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) are responsible for the removal of lipid-derived aldehydes. Isozyme ALDH3B2 probably acts to remove lipid-derived aldehydes in lipid droplets generated via oxidative stress as a quality control mechanism | Mus musculus |