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Literature summary for 1.2.1.5 extracted from

  • King, G.; Holmes, R.S.
    Human corneal aldehyde dehydrogenase: purification, kinetic characterisation and phenotypic variation (1993), Biochem. Mol. Biol. Int., 31, 49-63.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
p-hydroxymercuribenzoate 0.05 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.032
-
NAD+ reaction with benzaldehyde Homo sapiens
0.06
-
hexanal
-
Homo sapiens
0.1
-
trans-2-hexenal
-
Homo sapiens
0.2
-
benzaldehyde
-
Homo sapiens
0.49
-
NADP+ reaction with benzaldehyde Homo sapiens
67
-
acetaldehyde
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme plays a dual role in the absorption of UVR and in the oxidation of peroxidic aldehydes in the mammalian cornea ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
ALDH3
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cornea
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
46
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NAD+ + H2O
-
Homo sapiens acetate + NADH + H+
-
?
benzaldehyde + NAD+ + H2O
-
Homo sapiens benzoate + NADH + H+
-
?
benzaldehyde + NADP+
-
Homo sapiens benzoate + NADPH
-
?
hexanal + NAD+ + H2O
-
Homo sapiens hexanoate + NADH + H+
-
?
malondialdehyde + NAD+ no activity Homo sapiens ? + NADH
-
?
additional information enzyme plays a dual role in the absorption of UVR and in the oxidation of peroxidic aldehydes in the mammalian cornea Homo sapiens ?
-
?
trans-2-hexenal + NAD+
-
Homo sapiens trans-2-hexenoate + NADH
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
34
-
hexanal
-
Homo sapiens
35.9
-
acetaldehyde
-
Homo sapiens
38.8
-
NADP+ reaction with benzaldehyde Homo sapiens
45.3
-
NAD+ reaction with benzaldehyde Homo sapiens
51
-
benzaldehyde
-
Homo sapiens
53
-
trans-2-hexenal
-
Homo sapiens