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Literature summary for 1.2.1.5 extracted from

  • Bostian, K.A.; Betts, G.F.
    Kinetics and reaction mechanism of potassium-activated aldehyde dehydrogenase from Saccharomyces cerevisiae (1978), Biochem. J., 173, 787-798.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.5

Inhibitors

Inhibitors Comment Organism Structure
benzoate non-competitive with respect to either NAD+ or benzaldehyde Saccharomyces cerevisiae
NADH competitive with respect to NAD+ and non-competitive with respect to either benzaldehyde or glycolaldehyde Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
an aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H + H+ ordered bi bi mechanism with NAD+ as the leading substrate Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzaldehyde + NAD+ + H2O
-
 Saccharomyces cerevisiae benzoate + NADH + H+
-
 ?
glycolaldehyde + NAD+
-
 Saccharomyces cerevisiae glycolate + NADH
-
 ?
glycolaldehyde + NADP+ + H2O
-
 Saccharomyces cerevisiae glycolate + NADPH + H+
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
25
-
 90 min, about 80% loss of activity without a stabilizer, about 20% loss of activity in presence of 24% v/v of ethanediol Saccharomyces cerevisiae
25
-
 60 min, about 60% loss of activity without stabilizer, about 10% loss of activity in presence of 5 mM NAD+ Saccharomyces cerevisiae
25
-
 70 min, about 80% loss of activity without stabilizer, about 15% loss of activity in presence of 50 mM KCl Saccharomyces cerevisiae