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Literature summary for 1.2.1.5 extracted from

  • Glatt, H.; Rost, K.; Frank, H.; Seidel, A.; Kollock, R.
    Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1 (2008), Arch. Biochem. Biophys., 477, 196-205.
    View publication on PubMed
Search for more literature for 1.2.1.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli XL-1 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00078
-
 4-formylpyrene ALDH3A1, at pH 7.5 and 37°C Homo sapiens
0.0016
-
 1-formyl-6-methylpyrene ALDH3A1, at pH 7.5 and 37°C Homo sapiens
0.004
-
 1-formylpyrene ALDH3A1, at pH 7.5 and 37°C Homo sapiens
0.004
-
 1-formyl-8-methylpyrene ALDH3A1,at pH 7.5 and 37°C Homo sapiens
0.011
-
 2-formylpyrene ALDH3A1, at pH 7.5 and 37°C Homo sapiens
0.23
-
 benzaldehyde ALDH3A1, at pH 7.5 and 37°C Homo sapiens
12
-
 propionaldehyde ALDH3A1, at pH 7.5 and 37°C Homo sapiens
80
-
 acetaldehyde ALDH3A1, at pH 7.5 and 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P30838
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE MacroPrep column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
buccal mucosa
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-formyl-6-methylpyrene + NADP+ + H2O
-
 Homo sapiens 6-methylpyrene-1-carboxylic acid + NADPH + H+
-
 ?
1-formyl-8-methylpyrene + NADP+ + H2O
-
 Homo sapiens 8-methylpyrene-1-carboxylic acid + NADPH + H+
-
 ?
1-formylpyrene + NADP+ + H2O
-
 Homo sapiens pyrene-1-carboxylic acid + NADPH + H+
-
 ?
2-formylpyrene + NADP+ + H2O
-
 Homo sapiens pyrene-2-carboxylic acid + NADPH + H+
-
 ?
4-formylpyrene + NADP+ + H2O
-
 Homo sapiens pyrene-4-carboxylic acid + NADPH + H+
-
 ?
acetaldehyde + NADP+ + H2O
-
 Homo sapiens acetate + NADPH + H+
-
 ?
benzaldehyde + NADP+ + H2O
-
 Homo sapiens benzoate + NADPH + H+
-
 ?
formaldehyde + NADP+ + H2O
-
 Homo sapiens formate + NADPH + H+
-
 ?
propionaldehyde + NADP+ + H2O
-
 Homo sapiens propionate + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
ALDH3A1
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
7.4
-
 the activity at a physiological pH value (7.4) is nearly 50% of the activity observed at the optimal pH value Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens