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Literature summary for 1.2.1.59 extracted from

  • Jiang, L.; Zhang, Y.; Li, Z.; Liu, J.
    Metabolic engineering of Corynebacterium glutamicum for increasing the production of L-ornithine by increasing NADPH availability (2013), J. Ind. Microbiol. Biotechnol., 40, 1143-1151 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene gapC, recombinant overexpression in Corynebacterium glutamicum strain ATCC 13032, coexpression with Bacillus subtilis gene rocG encoding NAD+-dependent glutamate dehydrogenase, leading to increased L-ornithine biosynthesis in the engineered strain, overview. Quantitative real-time PCR expression analysis. Effects of overexpression of genes encoding enzymes in the upstream pathway of glutamate biosynthesis on L-ornithine production in Corynebacterium glutamicum DELTAAP. Overexpression of Clostridium acetobutylicum gapC increases the production of CoQ10 Clostridium acetobutylicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+ Clostridium acetobutylicum
-
3-phospho-D-glyceroyl phosphate + NADH + H+
-
?
D-glyceraldehyde 3-phosphate + phosphate + NADP+ Clostridium acetobutylicum
-
3-phospho-D-glyceroyl phosphate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Clostridium acetobutylicum O52631
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
Clostridium acetobutylicum 3-phospho-D-glyceroyl phosphate + NADH + H+
-
?
D-glyceraldehyde 3-phosphate + phosphate + NADP+
-
Clostridium acetobutylicum 3-phospho-D-glyceroyl phosphate + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
GAPC
-
Clostridium acetobutylicum
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
-
Clostridium acetobutylicum

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Clostridium acetobutylicum
NADP+
-
Clostridium acetobutylicum