Cloned (Comment) | Organism |
---|---|
single gene | Campylobacter jejuni |
Crystallization (Comment) | Organism |
---|---|
purified enzyme in complex with ADP, NAD+, and NADP+, X-ray diffraction structure determination and analysis at 2.05-2.25 A resolution | Campylobacter jejuni |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glyceraldehyde 3-phosphate + phosphate + NAD+ | Campylobacter jejuni | - |
3-phospho-D-glyceroyl phosphate + NADH + H+ | - |
? | |
D-glyceraldehyde 3-phosphate + phosphate + NADP+ | Campylobacter jejuni | - |
3-phospho-D-glyceroyl phosphate + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Campylobacter jejuni | A0A1E7PFR0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glyceraldehyde 3-phosphate + phosphate + NAD+ | - |
Campylobacter jejuni | 3-phospho-D-glyceroyl phosphate + NADH + H+ | - |
? | |
D-glyceraldehyde 3-phosphate + phosphate + NADP+ | - |
Campylobacter jejuni | 3-phospho-D-glyceroyl phosphate + NADPH + H+ | - |
? | |
additional information | the enzyme plays dual coenzyme specificity with NAD+ and NADP+ | Campylobacter jejuni | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
CjGAPDH | - |
Campylobacter jejuni |
GAPDH | - |
Campylobacter jejuni |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme plays dual coenzyme specificity with NAD+ and NADP+, binding structures analysis | Campylobacter jejuni | |
NAD+ | - |
Campylobacter jejuni | |
NADP+ | - |
Campylobacter jejuni |
General Information | Comment | Organism |
---|---|---|
physiological function | phosphorylating glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a ubiquitous cellular enzyme that has a defined role in glycolysis and other pathways where it catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate. The enzyme complexes with ADP and might be moonlighting | Campylobacter jejuni |