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Literature summary for 1.2.1.70 extracted from

  • Loida, P.J.; Thompson, R.L.; Walker, D.M.; CaJacob, C.A.
    Novel inhibitors of glutamyl-tRNA(Glu) reductase identified through cell-based screening of the heme/chlorophyll biosynthetic pathway (1999), Arch. Biochem. Biophys., 372, 230-237.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2,4-diphenyl-6-styryl-1-p-tolyl-pyridinium boron tetrafluoride IC50: 0.01 mM Arabidopsis thaliana
4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol IC50: 0.055 mM Arabidopsis thaliana
5,6-dichloro-1,3-benzodioxol-2-one IC50: 0.055 mM Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamyl-tRNAGlu + NADPH + H+ Arabidopsis thaliana the enzyme catalyzes the initial step of tetrapyrrole biosynthesis in plants and prokaryotes L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamyl-tRNAGlu + NADPH + H+
-
 Arabidopsis thaliana L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
 ?
L-glutamyl-tRNAGlu + NADPH + H+ the enzyme catalyzes the initial step of tetrapyrrole biosynthesis in plants and prokaryotes Arabidopsis thaliana L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Arabidopsis thaliana

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01
-
 IC50: 0.01 mM Arabidopsis thaliana 2,4-diphenyl-6-styryl-1-p-tolyl-pyridinium boron tetrafluoride
0.055
-
 IC50: 0.055 mM Arabidopsis thaliana 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
0.055
-
 IC50: 0.055 mM Arabidopsis thaliana 5,6-dichloro-1,3-benzodioxol-2-one