Literature summary for 1.2.1.79 extracted from

Jang, E.H.; Park, S.A.; Chi, Y.M.; Lee, K.S.
Structural insight into the substrate inhibition mechanism of NADP(+)-dependent succinic semialdehyde dehydrogenase from Streptococcus pyogenes (2015), Biochem. Biophys. Res. Commun., 461, 487-493.

Search for more literature for 1.2.1.79

Cloned(Commentary)

Cloned (Comment)	Organism
-	Streptococcus pyogenes

Crystallization (Commentary)

Crystallization (Comment)	Organism
structures in a binary complex with succinic semialdehyde as the substrate and a ternary complex with the substrate succinic semialdehyde and the inhibitory succinate semialdehyde, at 2.4 A resolution for both structures	Streptococcus pyogenes

Inhibitors

Inhibitors	Comment	Organism	Structure
succinate semialdehyde	uncompetitive substrate inhibition above 0.02 mM, in the presence of NADP+. Substrate inhibition is induced by the binding of inhibitory succinate semialdehyde in the cofactor-binding site, instead of NADP+	Streptococcus pyogenes

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.95	-	succinate semialdehyde	pH 7.0, 30°C	Streptococcus pyogenes

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pyogenes	A0A0J9X1M8	-	-
Streptococcus pyogenes MGAS1882	A0A0J9X1M8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinate semialdehyde + NADP+ + H2O	-	Streptococcus pyogenes	succinate + NADPH + 2 H+	-	?
succinate semialdehyde + NADP+ + H2O	-	Streptococcus pyogenes MGAS1882	succinate + NADPH + 2 H+	-	?

Synonyms

Synonyms	Comment	Organism
gabD	-	Streptococcus pyogenes
succinic semialdehyde dehydrogenase	-	Streptococcus pyogenes

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
1.69	-	succinate semialdehyde	pH 7.0, 30°C	Streptococcus pyogenes

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Streptococcus pyogenes

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.1	-	succinate semialdehyde	pH 7.0, 30°C	Streptococcus pyogenes

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
0.43	-	succinate semialdehyde	pH 7.0, 30°C	Streptococcus pyogenes

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Release 2023.1 (January 2023)