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Literature summary for 1.2.1.8 extracted from

  • Valenzuela-Soto, E.M.; Munoz-Clares, R.A.
    Betaine-aldehyde dehydrogenase from leaves of Amaranthus hypochondriacus L. exhibits an Iso Ordered Bi Bi steady state mechanism (1993), J. Biol. Chem., 268, 23818-23823.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
AMP competitive with respect to NAD+ and mixed with betaine aldehyde and uncompetitive with respect to NAD+ Amaranthus hypochondriacus
choline
-
 Amaranthus hypochondriacus
glycine betaine no inhibition up to 10 mM Amaranthus hypochondriacus
NADH mixed inhibitor against NAD+ and betaine aldehyde Amaranthus hypochondriacus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0395
-
 NAD+
-
 Amaranthus hypochondriacus
0.0561
-
 Betaine aldehyde
-
 Amaranthus hypochondriacus

Organism

Organism UniProt Comment Textmining
Amaranthus hypochondriacus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+ iso-ordered bi-bi steady state mechanism Amaranthus hypochondriacus
a
betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+ NAD+ is the first substrate to bind to the enzyme and NADH is the last product to dissociate from it Amaranthus hypochondriacus
a

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Amaranthus hypochondriacus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
betaine aldehyde + NAD+ + H2O
-
 Amaranthus hypochondriacus betaine + NADH
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.896
-
 AMP with respect to NAD+ Amaranthus hypochondriacus
4.1
-
 choline with respect to betaine aldehyde Amaranthus hypochondriacus