BRENDA - Enzyme Database show
show all sequences of 1.2.1.99

A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12

Kurihara, S.; Oda, S.; Kato, K.; Kim, H.G.; Koyanagi, T.; Kumagai, H.; Suzuki, H.; J. Biol. Chem. 280, 4602-4608 (2005)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
gamma-glutamyl-gamma-aminobutyraldehyde + NAD+ + H2O
Escherichia coli
the enzyme is involved in degradation of putrescine
4-(glutamylamino) butanoate + NADH + 2 H+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
P23883
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
gamma-glutamyl-gamma-aminobutyraldehyde + NAD+ + H2O
the enzyme is involved in degradation of putrescine
659502
Escherichia coli
4-(glutamylamino) butanoate + NADH + 2 H+
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
gamma-glutamyl-gamma-aminobutyraldehyde + NAD+ + H2O
Escherichia coli
the enzyme is involved in degradation of putrescine
4-(glutamylamino) butanoate + NADH + 2 H+
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
gamma-glutamyl-gamma-aminobutyraldehyde + NAD+ + H2O
the enzyme is involved in degradation of putrescine
659502
Escherichia coli
4-(glutamylamino) butanoate + NADH + 2 H+
-
-
-
?
Other publictions for EC 1.2.1.99
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724621
Ashok
Production of 3-hydroxypropion ...
Klebsiella pneumoniae
Biotechnol. Bioeng.
110
511-524
2013
-
1
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740617
Schneider
Pathway and enzyme redundancy ...
Escherichia coli
J. Bacteriol.
194
4080-4088
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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2
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-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
710985
Ashok
Development of recombinant Kle ...
Klebsiella pneumoniae, Klebsiella pneumoniae DSM 2026
Appl. Microbiol. Biotechnol.
90
1253-1265
2011
-
1
1
-
-
-
-
-
-
-
-
2
-
6
-
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2
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1
1
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2
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2
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711536
Raj
-
A novel NAD+-dependent aldehyd ...
Klebsiella pneumoniae, Klebsiella pneumoniae DSM 2026
Biotechnol. Bioprocess Eng.
15
131-138
2010
3
1
1
-
-
-
12
4
-
-
1
1
-
6
-
-
1
-
-
-
4
-
10
1
1
1
1
4
1
1
-
1
-
-
-
3
1
1
1
-
-
-
-
12
-
4
-
-
1
1
-
-
-
1
-
-
4
-
10
1
1
1
1
4
1
1
-
-
-
-
-
-
4
4
690591
Jo
Cloning, expression, and chara ...
Escherichia coli
Appl. Microbiol. Biotechnol.
81
51-60
2008
2
-
1
-
-
-
15
9
-
-
-
1
-
1
-
-
1
-
-
-
9
-
9
-
1
1
-
9
1
1
-
2
-
-
-
2
-
1
2
-
-
-
-
15
-
9
-
-
-
1
-
-
-
1
-
-
9
-
9
-
1
1
-
9
1
1
-
-
-
-
-
-
9
9
713388
Raj
-
Production of 3-hydroxypropion ...
Escherichia coli
Proc. Biochem.
32
1440-1446
2008
-
1
1
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
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-
-
-
-
-
-
-
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-
1
1
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-
-
1
-
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-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659502
Kurihara
A novel putrescine utilization ...
Escherichia coli
J. Biol. Chem.
280
4602-4608
2005
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-
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1
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1
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1
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1
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1
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