Any feedback?
Literature summary for 1.2.3.1 extracted from
- cDNA cloning, sequencing, and characterization of male and female rat liver aldehyde oxidase (rAOX1) (1999), J. Biol. Chem., 274, 3878-3886.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.355 | - |
N-methylnicotinamide | female rat liver enzyme after reduction with DTT | Rattus norvegicus |  |
| 0.36 | - |
N-methylnicotinamide | male rat liver enzyme after reduction with DTT | Rattus norvegicus | |
| 0.538 | - |
N-methylnicotinamide | male rat liver enzyme | Rattus norvegicus | |
| 1.063 | - |
N-methylnicotinamide | female rat liver enzyme | Rattus norvegicus | |
| 1.895 | - |
N-methylnicotinamide | female rat liver enzyme after reduction with DTT and reoxidation with 4,4'-dithiodipyridine | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | 2 Fe/S iron centres | Rattus norvegicus | |
| Mo5+ | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 150000 | - |
alpha2, 2 * 150000, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine | ? | - |
? | |
| additional information | Rattus norvegicus | enzyme is of interest as a source of the reactive oxygen species, hydrogen peroxide and the superoxide anion | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q9Z0U5 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| imidacloprid + H2O + O2 + N-methylnicotinamide | - |
Rattus norvegicus | nitroso-imidacloprid + amino-imidacloprid + H2O2 + ? | - |
? | |
| additional information | enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine | Rattus norvegicus | ? | - |
? | |
| additional information | enzyme is of interest as a source of the reactive oxygen species, hydrogen peroxide and the superoxide anion | Rattus norvegicus | ? | - |
? | |
| N1-methylnicotinamide + H2O + O2 | - |
Rattus norvegicus | N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | alpha2, 2 * 150000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AOX | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Rattus norvegicus | |
| molybdopterin | - |
Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
