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Literature summary for 1.2.3.1 extracted from

  • Panoutsopoulos, G.I.; Beedham, C.
    Kinetics and specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase towards substituted benzaldehydes (2004), Acta Biochim. Pol., 51, 649-663.
    View publication on PubMed
Search for more literature for 1.2.3.1

Inhibitors

Inhibitors Comment Organism Structure
3,4-Dihydroxybenzaldehyde 0.01 mM, 50% and 76% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM, 87% inhibition of 2-hydroxy-benzaldehyde oxidation Cavia porcellus
3,4-dimethoxy-2-phenylethylamine 0.1 mM and 1 mM, 48% and 100% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
3-Hydroxy-4-methoxybenzaldehyde 0.1 mM, 87% and 85% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM, 87% inhibition of 2-hydroxy-benzaldehyde oxidation Cavia porcellus
4-hydroxy-3-methoxy-2-phenylethylamine 0.1 mM and 1 mM, 21% and 55% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
catechol 0.1 mM and 1 mM, 64% and 98% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
dopamine 0.1 mM, 80% and 93% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM and 1 mM, 59% and 100% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
L-Dopa 0.1 mM and 1 mM, 39% and 94% inhibition of benzaldehyde oxidation, respectively Cavia porcellus
noradrenaline 0.1 mM, 51% and 95% inhibition of phenanthridine and N-methylphthalazine oxidation, respectively; 0.1 mM and 1 mM, 90% and 100% inhibition of benzaldehyde oxidation, respectively Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
 2-Methoxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
0.005
-
 3-Hydroxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
0.008
-
 4-hydroxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
0.019
-
 benzaldehyde 37°C, pH 7.0 Cavia porcellus
0.019
-
 3,4-dimethoxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
0.02
-
 3-Methoxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
0.02
-
 2-Hydroxybenzaldehyde 37°C, pH 7.0 Cavia porcellus
0.029
-
 3-Methoxy-4-hydroxybenzaldehyde 37°C, pH 7.0 Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
 Dunkin-Hartley guinea pigs
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation Cavia porcellus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxybenzaldehyde + H2O + O2
-
 Cavia porcellus 2-hydroxybenzoate + H2O2
-
 ?
2-methoxybenzaldehyde + H2O + O2
-
 Cavia porcellus 2-methoxybenzoate + H2O2
-
 ?
3,4-dimethoxybenzaldehyde + H2O + O2
-
 Cavia porcellus 3,4-dimethoxybenzoate + H2O2
-
 ?
3-hydroxybenzaldehyde + H2O + O2
-
 Cavia porcellus 3-hydroxybenzoate + H2O2
-
 ?
3-methoxy-4-hydroxybenzaldehyde + H2O + O2
-
 Cavia porcellus 3-methoxy-4-hydroxybenzoate + H2O2
-
 ?
3-methoxybenzaldehyde + H2O + O2
-
 Cavia porcellus 3-methoxybenzoate + H2O2
-
 ?
4-hydroxybenzaldehyde + H2O + O2
-
 Cavia porcellus 4-hydroxybenzoate + H2O2
-
 ?
4-methoxybenzaldehyde + H2O + O2
-
 Cavia porcellus 4-methoxybenzoate + H2O2
-
 ?
benzaldehyde + H2O + O2
-
 Cavia porcellus benzoate + H2O2
-
 ?
N-methylphthalazinium + O2 + H2O
-
 Cavia porcellus ?
-
 ?
phenanthridine + O2 + H2O
-
 Cavia porcellus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00016
-
 3,4-Dihydroxybenzaldehyde 37°C, pH 7.0, inhibition of 2-hydroxybenzaldehyde oxidation Cavia porcellus
0.00066
-
 3-Hydroxy-4-methoxybenzaldehyde 37°C, pH 7.0, inhibition of 2-hydroxybenzaldehyde oxidation Cavia porcellus