Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the trans-acting spxR regulatory gene positively regulates SpxB transcription in response to energy and metabolic state | Streptococcus pneumoniae D39 |
Application | Comment | Organism |
---|---|---|
additional information | spxB transcription is regulated by both cis- and trans-acting regulatory elements | Streptococcus pneumoniae D39 |
Protein Variants | Comment | Organism |
---|---|---|
G389D | spxB2 mutant, reduces H2O2 production to approximately that of a DELTAspxB null mutant. SpxB2 mutant shows an opaque colony phenotype and decreased production of H2O2 | Streptococcus pneumoniae D39 |
additional information | cis-acting mutations in spxB decrease H2O2 production. SpxB1 mutant with a 7 bp deletion (Datagaga) of one repeat unit of an adjacent direct repeat centres 136 bp upstream from the translation start codon of SpxB. SpxB1 mutant shows an opaque colony phenotype and decreased production of H2O2. SpxB transcript is greatly reduced (14fold) in the spxB1 mutant compared with parent strain D39. DELTAspxB deletion/insertion mutant, which forms large, opaque colonies on TSA plates similar to those of the spxB2 mutant, produces a minimal basal level of H2O2, and synthesizes capsule | Streptococcus pneumoniae D39 |
P449L | spxB4 mutant, reduces H2O2 production to approximately that of a DELTAspxB null mutant. SpxB4 mutant shows an opaque colony phenotype and decreased production of H2O2 | Streptococcus pneumoniae D39 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | Ala282Thr mutation in strain D39 reduces SpxB activity, probably by reducing FAD binding | Streptococcus pneumoniae D39 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae D39 | - |
serotype 2 | - |
Synonyms | Comment | Organism |
---|---|---|
SpxB | - |
Streptococcus pneumoniae D39 |