Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P16387 | Pda1, i.e. E1 component subunit alpha of pyruvate dehydrogenase complex, cf. EC 1.2.1.104 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | mitochondrial proteins, Pkp2 (Ygl059wp) and Ppp2 (Ycr079wp), are engaged in the regulation of the pyruvate dehydrogenase complex by affecting the phosphorylation state of subunit Pda1 | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
Pda1 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | mitochondrial proteins, Pkp2 (Ygl059wp) and Ppp2 (Ycr079wp), are engaged in the regulation of the pyruvate dehydrogenase complex by affecting the phosphorylation state of subunit Pda1. Ppp2 is almost exclusively localized in the mitochondrial matrix and associated with the complex. Cells lacking Ppp2 but also cells with a non-functional pyruvate dehydrogenase complex due to deletion of Pda1 possess similar sensitivity toward rapamycin | Saccharomyces cerevisiae |