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Literature summary for 1.2.4.2 extracted from
- 2-Oxoglutarate dehydrogenase is a more significant source of O2(-)/H2O2 than pyruvate dehydrogenase in cardiac and liver tissue (2016), Free Radic. Biol. Med., 97, 501-512.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Sus scrofa | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | Sus scrofa | - |
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Sus scrofa | - |
| liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Sus scrofa | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 2-oxoglutarate dehydrogenase | - |
Sus scrofa |
| OGDH | - |
Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Sus scrofa | |
| thiamine diphosphate | - |
Sus scrofa | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is a potent source of reactive oxygen species in liver and cardiac tissue | Sus scrofa |
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Release 2023.1 (January 2023)
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